Search Our Scientific Publications & Authors

Curr Top Dev Biol 2022 28;149:311-340. Epub 2022 Feb 28.

Developmental Signalling Laboratory, The Francis Crick Institute, London, United Kingdom. Electronic address:

Transforming growth factor β (TGF-β) family ligands play crucial roles in orchestrating early embryonic development. Most significantly, two family members, NODAL and BMP form signaling gradients and indeed in fish, frogs and sea urchins these two opposing gradients are sufficient to organize a complete embryonic axis. This review focuses on how these gradients are established and interpreted during early vertebrate development. Read More

ACS Nano 2022 May 23. Epub 2022 May 23.

CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry Chinese Academy of Sciences, Beijing 100190, China.

Biological ion pumps selectively transport target ions against the concentration gradient, a process that is crucial to maintaining the out-of-equilibrium states of cells. Building an ion pump with ion selectivity has been challenging. Here we show that a TiCT MXene film suspended in air with a trapezoidal shape spontaneously pumps K ions from the base end to the tip end and exhibits a K/Na selectivity of 4. Read More

J Comp Neurol 2022 May 23. Epub 2022 May 23.

Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Little is known about the development of the human entorhinal cortex (EC), a major hub in a widespread network for learning and memory, spatial navigation, high-order processing of object information, multimodal integration, attention and awareness, emotion, motivation, and perception of time. We analyzed a series of 20 fetal and two adult human brains using Nissl stain, acetylcholinesterase (AChE) histochemistry, and immunocytochemistry for myelin basic protein (MBP), neuronal nuclei antigen (NeuN), a pan-axonal neurofilament marker, and synaptophysin, as well as postmortem 3T MRI. In comparison with other parts of the cerebral cortex, the cytoarchitectural differentiation of the EC begins remarkably early, in the 10th week of gestation (w. Read More

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2022 May;38(5):452-459

Institute of Obstetrics, Gynecology and Reproduction, Department of Histology and Embryology, School of Medicine; Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Yangzhou University, Yangzhou 225001, China. *Corresponding author, E-mail:

Objective To generate rabbit polyclonal antibody against mouse Tubby(Tub)-like protein 2 (TULP2) and detect the expression of TULP2 in mouse testis. Methods pET30a (+)-TULP2 and pET30(+)-TULP2-C recombinant plasmids were constructed by inserting TULP2 full-length gene fragment and TULP2-C gene fragment containing Tub domain into pET30a (+). pET30a (+)-TULP2 and pET30(+)-TULP2-C were transformed into E. Read More

Ecol Evol 2022 May 15;12(5):e8884. Epub 2022 May 15.

Fisheries Research Institute of Kanagawa Prefecture Yokohama Japan.

Environmental heterogeneity is one of the most influential factors that create compositional variation among local communities. Greater compositional variation is expected when an environmental gradient encompasses the most severe conditions where species sorting is more likely to operate. However, evidence for stronger species sorting at severer environment has typically been obtained for less mobile organisms and tests are scarce for those with higher dispersal ability that allows individuals to sensitively respond to environmental stress. Read More