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A biomimetic anti-biofouling coating in nanofluidic channels.

Authors:
Sumire Fukuda Yan Xu

J Mater Chem B 2022 04 6;10(14):2481-2489. Epub 2022 Apr 6.

Department of Chemical Engineering, Graduate School of Engineering, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan.

Non-specific protein adsorption (NPA) is ubiquitous and generally considered a trigger for various biofoulings, adversely affecting diverse fields. Despite many approaches (generally polymer-based) available to combat NPA in a wide range of length scales, suppressing NPA in closed nanoscale spaces of emerging nanodevices such as nanofluidic devices remains a challenge due to the lack of suitable material and methodology to satisfy their ultra-small and closed features. In this study, a biomimetic, hydrosilane-functionalized 2-methacryloyloxyethyl phosphorylcholine (MPC) monomer material, which has tailored molecular characteristics and well-defined surface properties to overcome the challenges in the nanospaces, is elaborately designed and synthesized to form self-assembled, nanoscale, biomimetic coatings, enabling the efficient suppression of NPA in femtoliter-order, closed nanofluidic channels. The approach opens up a new path for exploring a strategic change of anti-biofouling coating from traditional polymer-based methodologies to a monomer-based methodology to overcome the challenge of suppressing NPA in closed nanospaces.

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http://dx.doi.org/10.1039/d1tb02627eDOI Listing
April 2022

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