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Case Report: An Unusual Case of Ectopic ACTH Syndrome Caused by Mediastinal Paraganglioma.

Authors:
Bo Li Zhe Yan Hui Huang

Front Endocrinol (Lausanne) 2021 5;12:790975. Epub 2022 Jan 5.

Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.

Ectopic adrenocorticotrophic hormone (ACTH) syndrome is not common, which is more unusual when caused by paraganglioma. We herein present a 40-year-old Chinese male who was diagnosed with ACTH-dependent Cushing's syndrome. However, the localization of the ACTH source was troublesome due to the inconsistent results of the high-dose dexamethasone suppression test and the desmopressin stimulation test. Bilateral inferior petrosal sinus sampling was performed, and ectopic ACTH syndrome was diagnosed. After Ga-DOTATATE-PET/CT and F-FDG-PET/CT were performed, it was localized in the anterior mediastinum. Post-operation histopathology demonstrated an ACTH-secreting mediastinal paraganglioma. The patient obtained complete clinical remission after a mediastinal tumorectomy.

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http://dx.doi.org/10.3389/fendo.2021.790975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769203PMC
March 2022

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