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Rev Esp Med Nucl Imagen Mol (Engl Ed) 2022 May-Jun;41(3):171-178. Epub 2021 May 26.

Marmara University School of Medicine, Division of Medical Oncology, Istanbul, Turkey. Electronic address:

Aim: We investigated the correlation between F-FDG PET/CT indices and pathological response in breast cancer treated with neoadjuvant chemotherapy (NACT) which was scored with Residual Cancer Burden (RCB) system after surgery. Our aim is to detect extensive residual cancer burden earlier by using PET/CT indices.

Methods: Characteristics of patients were retrieved retrospectively. Read More

Hum Pathol 2022 May 13. Epub 2022 May 13.

Department of pathology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. Electronic address:

Multifocal breast cancers are heterogeneous in terms of histologic characteristics and molecular types. In this study, we annotated multiple foci of invasive lesions and DCIS (ductal carcinoma in situ) lesions of 17 cases of multifocal breast cancer and investigated their immunohistochemical phenotypes (ER (estrogen receptor), PR (progesterone receptor), HER2 (human epidermal growth factor 2), Ki-67 proliferative index). Tumor histologic grade, proliferative index, and phenotypes were varied within each patient. Read More

Pathol Res Pract 2022 May 11;235:153943. Epub 2022 May 11.

State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an, China. Electronic address:

Objective: Breast cancer (BC) is the most commonly diagnosed cancer among females and has a poor prognosis, breast invasive ductal carcinoma is the most common histological type. The occurrence and development of BC is closely related to aberrant glucose metabolism. In the hyperglycemic environment caused by abnormal glucose metabolism, hypoxia-inducible factor-1 alpha (HIF-1α) enables tumor cells to absorb large amounts of glucose and enhance glycolysis by inducing the expression of glucose transporter type1 (GLUT1) and glycolysis genes, thus promoting tumor cell proliferation and metastasis. Read More

Eur J Radiol 2022 May 10;152:110323. Epub 2022 May 10.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, 17 Hsuchow Road, Taipei, Taiwan 100.

Purpose: To use mammographic tumour features (imaging biomarkers) to identify and investigate breast cancers originating from the terminal ductal lobular units (TDLUs) of the breast in order to overcome the confusion arising from the current histopathology terminology, which calls cancers arising from the TDLUs either "ductal" or "lobular".

Method: Prospectively collected data from a randomized controlled mammography screening trial with more than four decades of follow up, and data from the subsequent population-based service screening program in Dalarna County, Sweden, provided the database necessary for studying nonpalpable, primarily screen-detected breast cancer cases in their earliest detectable phases. Large format thick (subgross) and thin section histopathologic images of breast cancers originating from the TDLUs were correlated with their mammographic tumour features (imaging biomarkers) and long-term patient outcome. Read More

Front Oncol 2022 28;12:843598. Epub 2022 Apr 28.

Department of Breast and Thyroid Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.

Transfer RNA-derived small RNAs (tsRNAs) are conventional non-coding RNAs (ncRNAs) with a length between18 and 40 nucleotides (nt) playing a crucial role in treating various human diseases including tumours. Nowadays, with the use of high-throughput sequencing technologies, it has been proven that certain tsRNAs are dysregulated in multiple tumour tissues as well as in the blood serum of cancer patients. Meanwhile, data retrieved from the literature show that tsRNAs are correlated with the regulation of the hallmarks of cancer, modification of tumour microenvironment, and modulation of drug resistance. Read More