Secondary Hyperparathyroidism Before and After Bariatric Surgery: a Prospective Study with 2-Year Follow-Up.

Authors:

Mohamed AbdAlla Salman Ahmed Salman Ahmed Elewa Ahmed Rabiee Mohamed Tourky Hossam El-Din Shaaban Mohamed Issa Ahmed AbdAlla Mohammed Khattab Ahmed Refaat Ehab Fathy Usama Shaker Mohamed Khaled Noureldin Ahmed Moustafa Abd Al-Kareem Elias Mohamed Said Elmarzouky Mohamed Nasr Shazly Haitham S E Omar

Obes Surg 2022 04 20;32(4):1141-1148. Epub 2022 Jan 20.

General Surgery Department, Kasralainy School of Medicine, Cairo University, Cairo, Egypt.

Purpose: Secondary hyperparathyroidism (SHPT) is linked to obesity. Bariatric surgery may be associated with calcium and vitamin D deficiencies leading to SHPT. This study aimed to detect the prevalence of SHPT before and after bariatric surgery.

Methods: This prospective study assessed the prevalence of SHPT after sleeve gastrectomy (SG, n = 38) compared to one-anastomosis gastric bypass (OAGB, n = 86). All patients were followed up for 2 years. Bone mineral density (BMD) was assessed using dual-energy X-ray absorptiometry.

Results: Of the 124 patients, 71 (57.3%) were females, and 53 (42.7%) were males, with a mean age of 37.5 ± 8.8 years. Before surgery, 23 patients (18.5%) suffered from SHPT, and 40 (32.3%) had vitamin D deficiency. The prevalence of SHPT increased to 29.8% after 1 year and 36.3% after 2 years. SHPT was associated with lower levels of vitamin D and calcium and higher reduction of BMD in the hip but not in the spine. After 2 years, SHPT was associated with a significantly lower T-score in the hip. SHPT and vitamin D deficiency were significantly more common in patients subjected to OAGB compared to SG (p = 0.003, and p < 0.001, respectively). There is a strong negative correlation between vitamin D levels and parathormone levels before and after surgery.

Conclusion: Prevalence of SHPT is high in obese patients seeking bariatric surgery, especially with lower vitamin D levels. Bariatric surgery increases the prevalence of SHPT up to 2 years. Gastric bypass is associated with a higher risk of developing SHPT compared to SG.

Download full-text PDF	Source
http://dx.doi.org/10.1007/s11695-022-05902-7	DOI Listing

April 2022

Publication Analysis

Top Keywords

secondary hyperparathyroidism

Keyword Occurance

Similar Publications

Surgical management of secondary hyperparathyroidism in dialysis patients in Senegal.

Authors:

Maria Faye Niakhaleen Keita Ahmed Tall Lemrabott Ilham Algouzmari Moustapha Faye Mansour Mbengue Seynabou Diagne Bacary Ba Ameth Dieng Mamadou Aw Ba El Hadj Fary Ka

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1424-1430

Department of Nephrology, Cheikh Anta Diop University, Dakar, Senegal.

Secondary hyperparathyroidism (SHPT) is a common complication of end-stage renal disease. Surgical management occurs in severe forms and/or unresponsive medical treatment. The aim of this study was to outline the indications of parathyroidectomy and its evolution after surgical approach. Read More

View Article and Full-Text PDF

May 2022

Similar Publications

Secondary hyperparathyroidism (CKD-MBD) treatment and the risk of dementia.

Authors:

Aarti Mathur JiYoon B Ahn Whitney Sutton Nadia M Chu Alden L Gross Dorry L Segev Mara McAdams-DeMarco

Nephrol Dial Transplant 2022 May 5. Epub 2022 May 5.

Department of Surgery, New York University Langone Health, NY, NY, USA.

Background: Elevated parathyroid hormone (PTH) levels have been reported as a potential risk factor for cognitive impairment. Compared to the general population, older adults with end-stage renal disease (ESRD) who are frequently affected by secondary hyperparathyroidism (SHPT) are at increased risk of developing dementia. The main objective of our study was to evaluate if the risk of dementia in older (age ≥ 65) ESRD patients differed if they were treated for SHPT. Read More

View Article and Full-Text PDF

May 2022

Similar Publications

Peculiarities in the panoramic radiograph of patients with secondary hyperparathyroidism due to terminal renal disease: a radiologic controlled comparative study.

Authors:

Tobias Moest Arne Eric Jahn Katharina Heller Mario Schiffer Werner Adler Maximilian Rohde Manuel Weber Marco Rainer Kesting Rainer Lutz

Oral Radiol 2022 May 5. Epub 2022 May 5.

Department of Oral and Maxillofacial Surgery, University Hospital Erlangen, Glückstraße 11, 91054, Erlangen, Germany.

Objectives: The present radiological observational controlled study aims to evaluate the impact of secondary hyperparathyroidism (SHPT) due to chronic kidney disease (CKD) as well as the duration of dialysis on the mineralization of the mandible by standardized qualitative evaluation of digital panoramic radiographs.

Methods: Panoramic radiographs of CKD patients with SHPT and healthy controls were used for the qualitative analysis of the mandibular cortical index (MCI), the trabecular bone pattern (TBP), and calcification and resorption foci. Radiomorphometric indices were correlated to biochemical parameters and the duration of dialysis using the Spearman Rho test. Read More

View Article and Full-Text PDF

May 2022

Similar Publications

Risk factors for hypocalcemia in dialysis patients with refractory secondary hyperparathyroidism after parathyroidectomy: a meta-analysis.

Authors:

Dan Gao Yan Lou Yingchun Cui Shengmao Liu Wenpeng Cui Guangdong Sun

Ren Fail 2022 Dec;44(1):503-512

Department of Nephrology, The Second Hospital of Jilin University, Changchun, China.

Objective: Hypocalcemia after parathyroidectomy (PTX) results in tetany, diarrhea, cardiac arrhythmia, and even sudden death. However, a meta-analysis or systematic evaluation of risk factors with the occurrence and development of hypocalcemia in patients with secondary hyperparathyroidism (SHPT) after PTX has never been performed.

Methods: A thorough search of electronic databases, including PubMed, Web of Science, the Cochrane Library, and EMBASE, was performed to retrieve relevant studies from database inception to June 2021. Read More

View Article and Full-Text PDF

December 2022

Similar Publications

A single-center experience of parathyroidectomy in 1500 cases for secondary hyperparathyroidism: a retrospective study.

Authors:

Shasha Zhao Wei Gan Wenjia Xie Jinlong Cao Liang Zhang Ping Wen Junwei Yang Mingxia Xiong

Ren Fail 2022 Dec;44(1):23-29

Department of Nephrology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Chronic kidney disease (CKD) is a global public health problem. With the deterioration of renal function, a certain proportion of CKD patients enter the uremic stage, and secondary hyperparathyroidism (SHPT) becomes a challenge. For refractory hyperparathyroidism, parathyroidectomy (PTX) plays a key role in reducing mortality and improving prognosis. Read More

View Article and Full-Text PDF

December 2022

Similar Publications

}

Search Our Scientific Publications & Authors