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Nutr Cancer 2022 May 20:1-18. Epub 2022 May 20.

Unit of Biochemistry, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal.

Breast cancer constitutes the most incident cancer and one of the most common causes of cancer-related death. "Glutamine addiction", an important metabolic feature of cancer cells, is dependent on supply of this amino acid from external sources. In this study, the effect of several polyphenols (catechin, epicatechin, EGCG, catechin:lysine, naringenin, hesperidin, malvidin, delphinidin, kaempferol, quercetin, rutin, myricetin, resveratrol, xanthohumol, and chrysin) upon glutamine (H-GLN) uptake by human breast epithelial adenocarcinoma cell lines with distinct characteristics (MCF-7 and MDA-MB-231) was assessed. Read More

Nat Prod Res 2022 May 19:1-6. Epub 2022 May 19.

Department of Pharmacognosy, Semmelweis University, Budapest, Hungary.

The alkaloid profile of L. and subsp. (Kreyer) Avet have not been characterized yet. Read More

Food Chem 2022 May 5;390:133154. Epub 2022 May 5.

School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China; Collaborative Innovation Center for Food Production and Safety, School of Biological Science and Engineering, North Minzu University, Yinchuan 750000, China. Electronic address:

We evaluated the in vitro digestibility of apple polyphenols mimicking elderly and adult digestion models (dynamic and static systems). The digestibility of total apple polyphenols in small intestine was much higher in the adult dynamic system (62 μg/100 g fresh apple) compared to the static system (20 μg/100 g fresh apple) and elderly dynamic digestion conditions (33 μg/100 g fresh apple). Elderly in vitro static digestion showed better antioxidant activity than the adult system (OH and ABTS methods). Read More

ACS Omega 2022 May 29;7(18):16013-16027. Epub 2022 Apr 29.

Pharmacognosy Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt.

Column chromatography afforded the isolation of seven secondary metabolites (1-(2,4,6-trihydroxy phenyl)-ethanone-4--β-d-glucopyranoside, naringenin-7--β-d-glucopyranoside, kaempferol-3--α-l-rhamnoside, kaempferol-3--β-d-glucopyranoside, quercetin-3--β-d-glucopyranoside, quercetin-3--β-d-galactopyranoside, rutin) from the ethyl acetate (ET) fractions of Miq. stems (S), leaves (L), and fruits (F). Their identification based on ultraviolet (UV), electron ionization (EI), electrospray ionization-mass spectrometry (ESI-MS), and 1D and 2D NMR data. Read More

Molecules 2022 Apr 29;27(9). Epub 2022 Apr 29.

Department of Interfacial Phenomena, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Skłodowska University in Lublin, Maria Curie-Skłodowska Sq. 3, 20-031 Lublin, Poland.

Due to the increasing practical use of mixtures of flavonoids with nonionic surfactants the presented studies were based on the measurements of surface tension and conductivity of aqueous solution of the quercetin (Q) and rutin (Ru) in the mixtures with Triton X-114 (TX114) and Tween 80 (T80) as well as the contact angle of model liquids on the PTFE surface covered by the quercetin and rutin layers. Based on the obtained results components and parameters of the quercetin and rutin surface tension were determined and the mutual influence of Q and Ru in the mixtures with TX114 and T80 on their adsorption and volumetric properties were considered. It was found, among others, that based on the surface tension isotherms of the aqueous solution of the single flavonoid and nonionic surfactant, the surface tension isotherms of the aqueous solution of their mixture, the composition of the mixed monolayer at the water-air interface as well as the CMC of flavonoid + nonionic surfactant mixture can be predicted. Read More