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Molecular basis and clinical perspectives of deep brain stimulation for major depressive disorder.

Authors:
Saulo Araújo Teixeira Jorge Lucas de Sousa Moreira Narah Régia Tavares Sousa Andrezza Maria de Carvalho Pereira Paloma Nóbrega Rodrigues Adriano Siqueira Dos Santos Ana Maria Lima Carneiro de Andrade Modesto Leite Rolim Neto Jaime Emanuel Brito Araújo Sávio Samuel Feitosa Machado Nélio Barreto Vieira Danielly Gonçalves Sombra Lima Francisco Helder Pereira Filho

J Cereb Blood Flow Metab 2022 04 20;42(4):683-685. Epub 2022 Jan 20.

School of Medicine - Universidad Central del Paraguay - Sede 2 - Asunción, Paraguay.

It is possible to consider the stimulation of the cingulate gyrus in its portion below the corpus callosum (SCC, or subcallosal cingulate cortex) as an effective, promising, and safe alternative intervention for treatment-resistant depression. In studies with deep brain stimulation - DBS, when follow-on with functional magnetic resonance imaging and/or PET-CT (Positron emission tomography-computed tomography) is performed, it is observed an increase in the blood supply and glucose metabolism in this region, which is the anterior part of the limbic system. This same location has good experimental results also for the treatment of anorexia nervosa. The hypotheses suggest a greater activation of the reward system, a greater sense of well-being, and a consequent reduction in depressive symptoms, the objective of the treatment. Over the last 20 years, multicenter studies have shown symptomatic improvement in 50-60% of patients, and about a third even reach criteria for remission of the depressive disorder.

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http://dx.doi.org/10.1177/0271678X221074279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051149PMC
April 2022

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