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J Assoc Physicians India 2022 May;70(5):11-12

Resident, SKIMS, Srinagar, Jammu and Kashmir.

Aims And Objectives: Patients with pulmonary thromboembolism (PTE) are commonly admitted to hospital and generally have a prolonged hospital stay in this part of the world. We aimed to determine different clinical and laboratory parameters that are associated with prolonged hospital stay in our set-up and to analyse effectiveness of Pulmonary Embolism Severity Index (PESI) score as a predictor of prolonged hospital stay in patients with PTE.

Materials And Methods: It was a hospital based observational prospective study. Read More

Ann Neurol 2022 May 21. Epub 2022 May 21.

Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.

Objective: Evidence on associations of lifestyle factors with Alzheimer's pathology and cognition are ambiguous, potentially because they rarely addressed interrelationships of factors and sex effects. While considering these aspects, we examined the relationships of lifestyle factors with brain amyloid burden and cognition.

Methods: We studied 178 cognitively normal individuals (women, 49%; 65. Read More

J Hematol Oncol 2022 May 21;15(1):69. Epub 2022 May 21.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

International clinical practice guidelines have progressively endorsed direct oral anticoagulants (DOACs) as an alternative to low-molecular-weight heparins (LMWHs) monotherapy for the initial and long-term treatment of cancer-associated thrombosis (CAT). Several new randomized controlled trials (RCTs) have recently reported additional results on the safety and efficacy of DOACs in this setting. We performed an updated meta-analysis of all publicly available data from RCTs comparing DOACs with LMWHs for the treatment of CAT. Read More

Trials 2022 May 21;23(1):423. Epub 2022 May 21.

Department of Intensive Care Unit, Shengli Oilfield Central Hospital, Dongying, China.

Background: The specific use of methylprednisolone in severe community-acquired pneumonia (SCAP) has not yet formed a consensus. It is not clear whether the clinical efficacy of methylprednisolone in SCAP is dose-dependent, and how to balance the best efficacy with the least complications. The aim of this study is to evaluate the efficacy and safety of different doses of methylprednisolone in the adjuvant treatment for patients with SCAP. Read More

BMC Cardiovasc Disord 2022 May 21;22(1):237. Epub 2022 May 21.

Heart Institute (InCor) University of Sao Paulo Medical School Hospital, São Paulo, Brazil.

Background And Objective: Non-communicable diseases like systemic arterial hypertension (SAH) and dyslipidemia are poorly studied in terms of patient journey aspects. This semi-systematic review provides evidence synthesis for the management of SAH and dyslipidemia in Brazil and also discusses challenges faced by patients at the local level along with a suggested care approach by local experts.

Methods: A semi-systematic review using both structured literature databases (Embase and Medline) and unstructured scientific records (WHO, IPD, MOH and Google) on hypertension and dyslipidemia in the English language from 2010 to 2019 was performed by reviewers. Read More