Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

Acceptability and efficacy of the Zemedy app versus a relaxation training and meditation app for IBS: protocol for a randomised controlled trial.

Authors:
Melissa G Hunt Anika Dalvie Simay Ipek Ben Wasman

BMJ Open 2022 Jan 17;12(1):e055014. Epub 2022 Jan 17.

Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Introduction: Irritable bowel syndrome (IBS) has high rates of psychiatric comorbidity, and impairs health-related quality of life (HRQL). Cognitive-behavioural therapy (CBT) is an effective treatment for IBS, but access to treatment remains low. Our proposed solution is a CBT-based smartphone app, Zemedy.

Methods And Analysis: This randomised controlled trial of Zemedy (V.2.0) uses an education and relaxation training active control app meant to simulate treatment as usual. A target N of 300 participants complete baseline questionnaires and consent at screening, and are then allocated to either the immediate treatment (Zemedy) or the active control. Treatment lasts 8 weeks, after which both groups complete the same battery used at baseline, and the control group is crossed over to Zemedy. After another 8 weeks, the crossed-over participants will be surveyed once more. Follow-up questionnaires are administered at 3, 6 and 12 months post-treatment. Primary outcomes include gastrointestinal symptom severity and HRQL. Clinically significant change will be defined as post-treatment scores falling within 2 SD of the healthy mean. Analysis will include intent-to-treat between-groups comparisons, controlling for baseline symptom severity, as well as moderation and mediation analyses. We hypothesise that the Zemedy app will outperform the active control app in reducing IBS symptom severity and improving HRQL.

Ethics And Dissemination: This study was approved by the Institutional Review Board at the University of Pennsylvania. Results will provide essential information on the efficacy and acceptability of an app-based CBT treatment for IBS. The data gathered may help establish the Zemedy app as an empirically supported intervention for IBS and will assist funding bodies in deciding whether to invest in its further development and dissemination. The results will be disseminated to patients with IBS via the media and the company website, to healthcare professionals via professional training (e.g. webinars and grand rounds talks) and to researchers via conferences and publications.

Trial Registration Number: NCT04665271 (https://clinicaltrials.gov/ct2/show/NCT04665271).

Download full-text PDF

 Source
http://dx.doi.org/10.1136/bmjopen-2021-055014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765021PMC
January 2022

Publication Analysis

Top Keywords

active control
12
symptom severity
12
zemedy app
12
randomised controlled
8
controlled trial
8
treatment ibs
8
relaxation training
8
control app
8
app
7
will
7
ibs
7
treatment
6
zemedy
6
weeks groups
4
complete battery
4
review board
4
groups complete
4
lasts weeks
4
institutional review
4
nct04665271 https//clinicaltrialsgov/ct2/show/nct04665271
4

Keyword Occurance

Similar Publications

A SARS-CoV-2 outbreak associated with vaccine breakthrough in an acute care hospital.

Authors:
Se Yoon Park Tae Hyong Kim Eunjung Lee Mark Loeb Yeon Su Jeong Jin Hwa Kim Sun Mi Oh Sojin Cheong Hyein Park SoYea Jo Ji Woo Sim

Am J Infect Control 2022 May 20. Epub 2022 May 20.

Infectious Disease Control Division Citizens' Health Bureau, Seoul Metropolitan Government, Seoul, Republic of Korea.

Background: We aimed to analyze an outbreak caused by a vaccine breakthrough infection in a hospital with an active infection control program where 91.9% of health care workers were vaccinated.

Methods: We investigated a SARS-CoV-2 outbreak between September 9 and October 2, 2021, in a referral teaching hospital in Korea. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Could allicin alleviate trastuzumab-induced cardiotoxicity in a rat model through antioxidant, anti-inflammatory, and antihyperlipidemic properties?

Authors:
Ayman M Mousa Khaled E A Soliman Fahad A Alhumaydhi Ahmad Almatroudi Khaled S Allemailem Mohammed A Alsahli Faris Alrumaihi Mohammad Aljasir Ameen S S Alwashmi Ahmed A Ahmed Arif Khan Khalid A Al-Regaiey Naif AlSuhaymi Mahdi H Alsugoor Walid A Aljarbou Abulmaaty M Elsayed

Life Sci 2022 May 20:120656. Epub 2022 May 20.

Department of Anatomy and Histology, Faculty of Medicine, Mutah University, Mutah, Jordan; Department of Anatomy and Embryology, Faculty of Medicine, Benha University, Benha 13518, Egypt. Electronic address:

Aims: Although trastuzumab (TZB)-induced cardiotoxicity is well documented and allicin (one of the main active garlic ingredients) has ameliorating effects against numerous causes of toxicities; however, the influence of allicin on TZB-induced cardiotoxicity has not been investigated yet. Therefore, the current work explored the potential cardioprotective structural, biochemical, and molecular mechanisms of allicin against TZB-induced cardiotoxicity in a rat's model.

Methods: Forty rats were divided into four equal groups and treated for five weeks. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Saroglitazar is non-inferior to fenofibrate in reducing triglyceride levels in hypertriglyceridemic patients in a randomized clinical trial.

Authors:
Rene Rodriguez-Gutierrez Jose Gerardo González Deven Parmar Farheen Shaikh Pio Cruz-López

J Lipid Res 2022 May 20:100233. Epub 2022 May 20.

Avant Sante Research Center SA de CV., Clinical Development, Monterrey, Mexico.

Saroglitazar, being a dual PPAR-α/γ agonist, has shown beneficial effect in diabetic dyslipidemia and hypertriglyceridemia. Fibrates are commonly used to treat severe hypertriglyceridemia. However, effect of saroglitazar in patients with moderate to severe hypertriglyceridemia was not evaluated. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

The role of dissolved organic matter during Per- and Polyfluorinated Substance (PFAS) adsorption, degradation, and plant uptake: A review.

Authors:
Yuwen Qi Huimin Cao Weijie Pan Cuiping Wang Yanna Liang

J Hazard Mater 2022 May 16;436:129139. Epub 2022 May 16.

Department of Environmental and Sustainable Engineering, University at Albany, SUNY, Albany, NY 12222, USA.

The negative effects of polyfluoroalkyl substances (PFAS) on the environment and health have recently attracted much attention. This article reviews the influence of soil- and water-derived dissolved organic matter (DOM) on the environmental fate of PFAS. In addition to being co-adsorped with PFAS to increase the adsorption capacity, DOM competes with PFAS for adsorption sites on the surface of the material, thereby reducing the removal rate of PFAS or increasing water solubility, which facilitates desorption of PFAS in the soil. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Microelectronic structure changes electron utilization: Core-shell structure catalysts with electron library and quantum dots for photocatalytic hydrogen production.

Authors:
Ling Ding Zebin Yu Lei Sun Ronghua Jiang Yanping Hou Jun Huang Hongxiang Zhu Tao Zhong Huajiao Chen Cuifang Lian

J Colloid Interface Sci 2022 May 16;623:660-673. Epub 2022 May 16.

MOE Key Laboratory of New Processing Technology for Norferrous Metals and Materials, Guangxi key Laboratory of Processing for Norferrous Featured Metals and Materials, School of Resources, Environment and Materials, Nanning 530004 Guangxi, PR China.

Photocatalysis is facing huge challenges especially the separation and efficient utilization of photocarriers. Herein, we report that a ternary hollow core-shell photocatalyst is synthesized by template and self-assembled method. The experimental results show that the electron separation efficiency and utilization efficiency are significantly improved, not only because the ternary hollow core-shell structure spatially separates the oxidation area MnOx from the reduction area Co-MOF, but also because lots of emergent electrons are stored in Co-MOF as an electronic library, contributing to the formation of surface polarization to support the requirement call from the CoP quantum dots (QDs) as active-sites. Read More

View Article and Full-Text PDF
May 2022
Similar Publications
}