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J Neurol Neurosurg Psychiatry 2022 May 16. Epub 2022 May 16.

Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, University College London Hospitals NHS Foundation Trust, London, UK.

In the last 6 years, following the first pathological description of presumed amyloid-beta (Aβ) transmission in humans (in 2015) and subsequent experimental confirmation (in 2018), clinical cases of iatrogenic cerebral amyloid angiopathy (CAA)-attributed to the transmission of Aβ seeds-have been increasingly recognised and reported. This newly described form of CAA is associated with early disease onset (typically in the third to fifth decade), and often presents with intracerebral haemorrhage, but also seizures and cognitive impairment. Although assumed to be rare, it is important that clinicians remain vigilant for potential cases, particularly as the optimal management, prognosis, true incidence and public health implications remain unknown. Read More

Pharmacol Res 2022 May 13:106260. Epub 2022 May 13.

School of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia. Electronic address:

Heat shock protein 90 (Hsp90) has evolved as a cancerous cell growth regulator by stabilising various oncogenic kinases. Upon the Hsp90 inhibition, the expression of its client proteins is downregulated and thus leads to denaturation of cellular proteins and cancer cell death. Hsp90 inhibitors, particularly those naturally derived from plants, fungi and bacteria, have gained substantial interest as a feasible therapeutic approach for cancer treatment due to their diverse pharmacological properties. Read More

Cir Esp (Engl Ed) 2022 May 13. Epub 2022 May 13.

Servicio de Cirugía Torácica, Hospital Álvaro Cunqueiro, Vigo, Pontevedra, Spain.

Introduction: Inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT) are two very rare entities that were formerly included in the same category; however, today they are considered two different diseases due to the neoplastic origin of the IMT. Our objective is to share our experience in the management of these two types of tumors that we must take into account in the differential diagnosis of pulmonary masses or nodules.

Methods: Thirteen patients with a pathological diagnosis of IPT and IMT who underwent surgery between 2008 and 2019 were retrospectively studied. Read More

Int J Infect Dis 2022 May 13. Epub 2022 May 13.

Intern, Oral & Maxillofacial Surgery Dept, Lagos State University Teaching Hospital, Lagos, Nigeria.

Introduction: There remain challenges using SARS-CoV-2 RNA diagnostic assays in the respiratory tract, in a pandemic. More so certain countries such as Hong-Kong have already included saliva as part of their mass-testing protocol. The aim of this study is to conduct a systematic review on the alternate use of saliva as a SARS-CoV2 RNA testing specimen in the context of mass screening with RT-PCR. Read More

Uisahak 2022 Apr;31(1):1-34

Associate Professor, College of Korean Medicine, Daejeon University; Research Fellow, The Institute for Medical Humanities, Inje University.

In this research, I analyzed Stray notes with experienced tests, a medical book written by I Sugi, a physician of Joseon dynasty, to check the trend of clinical medicine and the reasoning prevalent among Joseon physicians in the seventeenth and eighteenth centuries. I Sugi's medical science can be sorted into diagnosis and treatment. For accurate diagnosis, there had to be examinations and analysis on the nature of a disease. Read More