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Quality of Life of Children Born with a Congenital Heart Defect.

Authors:
Neil Derridj Damien Bonnet Johanna Calderon Pascal Amedro Nathalie Bertille Nathalie Lelong Francois Goffinet Babak Khoshnood Romain Guedj

J Pediatr 2022 05 13;244:148-153.e5. Epub 2022 Jan 13.

Center of Research in Epidemiology and Statistics, Inserm, INRA, University of Paris, Paris, France; Pediatric Emergency Department, Faculty of Medicine, AP-HP, Armand Trousseau Hospital, Sorbonne University, Paris, France.

Objectives: To identify subgroups with a congenital heart defect (CHD) at risk of health-related quality of life (QoL) impairment at 8 years of age according to their medical and surgical management.

Study Design: From a prospective population-based cohort study, 598 patients with CHD were subdivided according to their medical and surgical management: (1) CHD followed-up in an outpatient clinic, (2) complete repair before age 3 years, (3) complete repair after age 3 years, (4) palliative repair, or (5) CHD with spontaneous resolution (reference subgroup). Self-reported QoL and parent-reported QoL were measured using the Pediatric Quality of Life Inventory version 4.0 (score range, 0-100) at age 8 years. Multivariable regression analysis and Cohen effect size were used to compare outcomes across the CHD groups.

Results: Self-reported and parent-reported QoL scores for the palliative repair subgroup were lower (β = -2.1 [95% CI, -3.9 to -0.2] and β = -16.0 [95% CI, -22.4 to -9.5], respectively), with a large effect size (δ = -0.9 [95% CI, -1.4 to -0.4] and δ = -1.3 [95% CI, -1.8 to -0.7], respectively). Parent-reported QoL scores for the complete repair after age 3 years subgroup were lower (β = -9.2; 95% CI, -15.0 to -3.5), with a large effect size (δ = -0.9; 95% CI, -1.4 to -0.5). Self-reported QoL scores for the complete repair before age 3 years subgroup was lower (β = -1.3; 95% CI, -1.9 to -0.6), with a small effect size (δ = -0.4; 95% CI, -0.6 to -0.2).

Conclusions: The QoL of children with CHD who experienced a hospital intervention is reduced at age 8 years. Patient age at the last cardiac intervention might influence QoL at 8 years.

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http://dx.doi.org/10.1016/j.jpeds.2022.01.003DOI Listing
May 2022

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