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J Appl Toxicol 2022 Mar 8. Epub 2022 Mar 8.

Golikov Research Clinical Center of Toxicology under the Federal Medical Biological Agency, Saint Petersburg, Russia.

The vascular endothelium is not only the semipermeable membrane that separates tissue from blood but also an organ that regulates inflammation, vascular tone, blood clotting, angiogenesis and synthesis of connective tissue proteins. It is susceptible to the direct cytotoxic action of numerous xenobiotics and to the acute hypoxia that accompanies acute poisoning. This damage is superimposed on the preformed state of the vascular endothelium, which, in turn, depends on many humoral factors. Read More

Kidney Int 2022 Jun 11;101(6):1171-1185. Epub 2022 Jan 11.

Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Septomics Research Center, Jena University Hospital, Jena, Germany; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany. Electronic address:

Thrombotic microangiopathy, hemolysis and acute kidney injury are typical clinical characteristics of hemolytic-uremic syndrome (HUS), which is predominantly caused by Shiga-toxin-producing Escherichia coli. Free heme aggravates organ damage in life-threatening infections, even with a low degree of systemic hemolysis. Therefore, we hypothesized that the presence of the hemoglobin- and the heme-scavenging proteins, haptoglobin and hemopexin, respectively impacts outcome and kidney pathology in HUS. Read More

Am J Trop Med Hyg 2021 09 27;105(5):1163-1172. Epub 2021 Sep 27.

Morehouse School of Medicine, Atlanta, Georgia.

In malaria endemic countries, anemia in pregnant women occurs as a result of erythrocyte destruction by Plasmodium infections and other causes including malnutrition. Iron supplementation is recommended as treatment of iron-deficiency anemia. Erythrocyte destruction results in increased release of cytotoxic free heme that is scavenged by haptoglobin (Hp), hemopexin (Hx) and heme oxygenase-1 (HO-1). Read More

Mol Pharm 2021 08 22;18(8):3158-3170. Epub 2021 Jul 22.

Division of Internal Medicine, Universitätsspital and University of Zurich, Zurich 8091, Switzerland.

Cell-free hemoglobin (Hb) is a driver of disease progression in conditions with intravascular or localized hemolysis. Genetic and acquired anemias or emergency medical conditions such as aneurysmal subarachnoid hemorrhage involve tissue Hb exposure. Haptoglobin (Hp) captures Hb in an irreversible protein complex and prevents its pathophysiological contributions to vascular nitric oxide depletion and tissue oxidation. Read More

Clin Kidney J 2021 Jul 14;14(7):1826-1834. Epub 2020 Dec 14.

Institut de Recerca Biomedica August Pi Sunyer, Lleida, Barcelona, Spain.

Objectives: Idiopathic focal segmental glomerulosclerosis (FSGS) has been linked to immunological and inflammatory response dysregulations. The aim of this study was to find endotypes of FSGS patients using a cluster (CL) analysis based on inflammatory and immunological variables, and to analyse whether a certain endotype is associated with response to treatment with corticosteroids.

Methods: This prospective observational study included patients with idiopathic FSGS diagnosed by kidney biopsy. Read More