Blood Adv 2022 Jan 13. Epub 2022 Jan 13.
University of Zurich and University Hospital Zurich, Zurich, Switzerland.
Leukemia 2022 Feb 19;36(2):327-332. Epub 2022 Jan 19.
Division of Hematopathology, Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.
JAMA Intern Med 2022 Jan 18. Epub 2022 Jan 18.
Medical Clinic III, Gastroenterology, Metabolic diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
Importance: Telomeres protect DNA from damage. Because they shorten with each mitotic cycle, leukocyte telomere length (LTL) serves as a mitotic clock. Reduced LTL has been associated with multiple human disorders. Read More
iScience 2022 Jan 25;25(1):103679. Epub 2021 Dec 25.
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Abnormal activation of due to overexpression or missense mutations occurs frequently in various myeloid neoplasms and associates with poor prognosis. Direct activation of transcription by SETBP1 and its missense mutants is essential for their transforming capability; however, the underlying epigenetic mechanisms remain elusive. We found that both SETBP1 and its missense mutant SETBP1(D/N) directly interact with histone methyltransferase MLL1. Read More
BMC Med Genomics 2022 Jan 15;15(1):10. Epub 2022 Jan 15.
Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Selangor, Malaysia.
Background: The Philadelphia (Ph)-negative myeloproliferative neoplasms (MPNs), namely essential thrombocythaemia (ET), polycythaemia vera (PV) and primary myelofibrosis (PMF), are a group of chronic clonal haematopoietic disorders that have the propensity to advance into bone marrow failure or acute myeloid leukaemia; often resulting in fatality. Although driver mutations have been identified in these MPNs, subtype-specific markers of the disease have yet to be discovered. Next-generation sequencing (NGS) technology can potentially improve the clinical management of MPNs by allowing for the simultaneous screening of many disease-associated genes. Read More
J Allergy Clin Immunol Pract 2022 Jan 12. Epub 2022 Jan 12.
Allergy & Immunology Service, Walter Reed National Military Medical Center, Bethesda MD; Department of Medicine, Uniformed Services University, Bethesda, MD. Electronic address:
Background: Hereditary-alpha tryptasemia (HαT) is the most common etiology for elevated basal serum tryptase (BST). However, the utility of tryptase genotyping of individuals with elevated BST in general clinical practice remains undefined. Moreover, studies showing associations between elevated BST and chronic kidney disease (CKD), myelodysplastic syndrome (MDS), rheumatoid arthritis (RA), or eosinophilic esophagitis (EoE) did not include tryptase genotyping. Read More