Oral Oncol 2022 Jan 10;125:105696. Epub 2022 Jan 10.
Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada; Institut du cancer de Montréal, Montreal, QC, Canada; Otolaryngology-Head and Neck Surgery Service, Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada. Electronic address:
Biochem Biophys Res Commun 2022 Jan 19;594:109-116. Epub 2022 Jan 19.
Department of Biomedical Sciences, National Chung Cheng University, Chia-Yi, 621, Taiwan. Electronic address:
HIC1 and RassF1A methylation, which cause loss of gene function, are found in various cancers, including renal cell carcinoma (RCC), and could alter cell stiffness and the content of extracellular vesicles (EVs). These physiological changes may provide a tumoral survival advantage and thus could serve as cellular biomarkers for monitoring cell transformation, although direct associations between these changes and cell transformation remain to be established. As we found HIC1 and RassF1A methylation and expression changes in RCC samples, we examined the effects of gain and loss of HIC1 and RassF1A expression on cell DNA content, cytoskeletal structure, and Piwi-interacting RNA (piRNA) expression in EVs. Read More
Cancer Cytopathol 2022 Jan 26. Epub 2022 Jan 26.
Department of Pathology, Catholic University of Sacred Heart University, Rome, Italy.
Background: Pediatric salivary gland fine-needle aspiration (FNA) is uncommon with a higher frequency of inflammatory lesions and a small proportion of malignancies. This international, multi-institutional cohort evaluated the application of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) and the risk of malignancy (ROM) for each diagnostic category.Methods: Pediatric (0- to 21-year-old) salivary gland FNA specimens from 22 international institutions of 7 countries, including the United States, England, Italy, Greece, Finland, Brazil, and France, were retrospectively assigned to an MSRSGC diagnostic category as follows: nondiagnostic, nonneoplastic, atypia of undetermined significance (AUS), benign neoplasm, salivary gland neoplasm of uncertain malignant potential (SUMP), suspicious for malignancy (SM), or malignant. Read More
PLoS One 2022 26;17(1):e0258998. Epub 2022 Jan 26.
Department of Pharmacology, National Research Centre, Dokki, Cairo, Egypt.
Hepatocellular carcinoma (HCC) is one of the most burdened tumors worldwide, with a complex and multifactorial pathogenesis. Current treatment approaches involve different molecular targets. Phytochemicals have shown considerable promise in the prevention and treatment of HCC. Read More
Mol Biol Cell 2022 Jan 26:mbcE21030143. Epub 2022 Jan 26.
ReMedy International Research Agenda Unit, IMol Polish Academy of Sciences, Warsaw, Poland.
Assembly of the dimeric complex III (CIII) in the mitochondrial inner membrane is an intricate process, in which several accessory proteins are involved as assembly factors. Despite numerous studies, this process is yet to be fully understood. Here we report the identification of human OCIAD2 (Ovarian Carcinoma Immunoreactive Antigen domain containing protein 2) protein as an assembly factor for CIII. Read More
Can J Physiol Pharmacol 2022 Jan 26:1-9. Epub 2022 Jan 26.
Department of General Surgery, Traditional Chinese Medicine Hospital of Muping District of Yantai City, No. 505 Government Street, Yantai, 264100, Shangdong province, China.
Nasopharyngeal carcinoma (NC) poses a threat to the life of patients. Long non-coding RNA (LncRNA) is a novel kind of non-coding RNA, which plays a pivotal role through sponge microRNA (miRNA). Abnormal expression of small nucleolar RNA host gene 8 () is involved in various tumors; however, the role of in NC remains unknown. Read More