Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy.

Authors:
Xiao-Xu Yang Zhen-Yu Zhao

Can J Physiol Pharmacol 2022 Feb 13;100(2):167-175. Epub 2022 Jan 13.

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China.

Cardiac fibrosis is one of the major pathological characteristics of diabetic cardiomyopathy (DCM). MicroRNAs (miRNAs, miRs) have been identified as key regulators in the progression of cardiac fibrosis. This study aimed to investigate the role of in DCM and the underlying mechanism. The rat model of diabetes mellitus (DM) was established by streptozotocin injection, and the rat primary cardiac fibroblasts (CFs) were isolated from cardiac tissue and then treated with high glucose (HG). MTT assay was performed to assess the viability of CFs. Dual-luciferase reporter gene assay was conducted to verify the interaction between and . The expression of was downregulated in the myocardial tissues of DM rats and HG-stimulated CFs. Overexpression of reduced levels and inhibited collagen formation in HG-stimulated CFs and DM rats, as well as decreased the proliferation of CFs induced by HG. was a target of and its expression was inhibited by . Furthermore, the simultaneous overexpression of and reversed the effect of overexpression alone in CFs. Our results indicated that reduced expression and also induced a decrease in proliferation and collagen formation in DCM.

Download full-text PDF

 Source
http://dx.doi.org/10.1139/cjpp-2021-0280DOI Listing
February 2022

Publication Analysis

Top Keywords

collagen formation
12
diabetic cardiomyopathy
8
cardiac fibroblasts
8
proliferation collagen
8
hg-stimulated cfs
8
cardiac fibrosis
8
cfs
6
cardiac
5
fibroblasts cfs
4
well decreased
4
cfs isolated
4
mir-30a-5p inhibits
4
isolated cardiac
4
cardiac tissue
4
tissue treated
4
rats well
4
treated high
4
primary cardiac
4
formation dcm
4
rat primary
4

Keyword Occurance

Similar Publications

Functional role of inorganic trace elements in dentin apatite-Part II: Copper, manganese, silicon, and lithium.

Authors:
Mohammad Ali Saghiri Julia Vakhnovetsky Anna Vakhnovetsky

J Trace Elem Med Biol 2022 May 7;72:126995. Epub 2022 May 7.

Pre-Medical Student, Johns Hopkins University, Baltimore, MD, United States.

Trace elements are recognized as being essential in dentin and bone apatite. The effects of zinc, strontium, magnesium, and iron were discussed in part I. In part II, we evaluated the functional role of copper, manganese, silicon, and lithium on dentin apatite, with critical effects on morphology, crystallinity, and solubility. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Modulation of Differentiation and Bone Resorbing Activity of Human (Pre-) Osteoclasts After X-Ray Exposure.

Authors:
Denise Eckert Felicitas Rapp Ayele Taddese Tsedeke Daniela Kraft Isabell Wente Jessica Molendowska Sidra Basheer Markus Langhans Tobias Meckel Thomas Friedrich Anna-Jasmina Donaubauer Ina Becker Benjamin Frey Claudia Fournier

Front Immunol 2022 4;13:817281. Epub 2022 May 4.

Department of Biophysics, Gesellschaft für Schwerionenforschung (GSI) Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.

Low-dose radiotherapy (LD-RT) is a local treatment option for patients with chronic degenerative and inflammatory diseases, in particular musculoskeletal diseases. Despite reported analgesic and anti-inflammatory effects, cellular and molecular mechanisms related to osteoimmunological effects are still elusive. Here we test the hypothesis that X-irradiation inhibits the differentiation of precursor osteoclasts into mature osteoclasts (mOC) and their bone resorbing activity. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Inonotsuoxide B suppresses hepatic stellate cell activation and proliferation via the PI3K/AKT and ERK1/2 pathway.

Authors:
Juan Jin Hui Yang Lili Hu Yinghong Wang Wenyong Wu Chengmu Hu Kun Wu Zehua Wu Wenming Cheng Yan Huang

Exp Ther Med 2022 Jun 28;23(6):417. Epub 2022 Apr 28.

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230032, P.R. China.

Hepatic stellate cells (HSCs) serve a pivotal role in the formation and degradation of the extracellular matrix during liver fibrosis. Inonotsuoxide B is a tetracyclic triterpenoid that can be extracted from and has been previously reported to inhibit the growth of liver and gastric cancer cells. However, its effect on liver fibrosis remain poorly understood. Read More

View Article and Full-Text PDF
June 2022
Similar Publications

The Antifibrotic and the Anticarcinogenic Activity of Capsaicin in Hot Chili Pepper in Relation to Oral Submucous Fibrosis.

Authors:
Zoufang Huang Mohit Sharma Aparna Dave Yuqi Yang Zhe-Sheng Chen Raghu Radhakrishnan

Front Pharmacol 2022 4;13:888280. Epub 2022 May 4.

Department of Oral Pathology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, India.

A burning sensation on eating spicy foods purportedly supports the role of capsaicin, an active component of chili peppers, in the etiology of oral submucous fibrosis (OSF). Although the mast cell mediators and activated P2X receptors induce a constant burning sensation through an ATP-dependent mechanism, it is the activation of the transient receptor potential vanilloid 1 (TRPV-1) receptor by capsaicin that aggravates it. The molecular basis for the burning pain in OSF is thus attributable to the activation of TRPV1. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

In vitro maturation and in vivo stability of bioprinted human nasal cartilage.

Authors:
Xiaoyi Lan Yan Liang Margaret Vyhlidal Esra Jn Erkut Melanie Kunze Aillette Mulet-Sierra Martin Osswald Khalid Ansari Hadi Seikaly Yaman Boluk Adetola B Adesida

J Tissue Eng 2022 Jan-Dec;13:20417314221086368. Epub 2022 Mar 17.

Division of Orthopedic Surgery and Surgical Research, Department of Surgery, University of Alberta, Edmonton, AB, Canada.

The removal of skin cancer lesions on the nose often results in the loss of nasal cartilage. The cartilage loss is either surgically replaced with autologous cartilage or synthetic grafts. However, these replacement options come with donor-site morbidity and resorption issues. Read More

View Article and Full-Text PDF
March 2022
Similar Publications
}