Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

DIC in Pregnancy - Pathophysiology, Clinical Characteristics, Diagnostic Scores, and Treatments.

Authors:
Offer Erez Maha Othman Anat Rabinovich Elad Leron Francesca Gotsch Jecko Thachil

J Blood Med 2022 6;13:21-44. Epub 2022 Jan 6.

Department of Haematology, Manchester Royal Infirmary, Manchester, UK.

Obstetrical hemorrhage and especially DIC (disseminated intravascular coagulation) is a leading cause for maternal mortality across the globe, often secondary to underlying maternal and/or fetal complications including placental abruption, amniotic fluid embolism, HELLP syndrome (hemolysis, elevated liver enzymes and low platelets), retained stillbirth and acute fatty liver of pregnancy. Various obstetrical disorders can present with DIC as a complication; thus, increased awareness is key to diagnosing the condition. DIC patients can present to clinicians who may not be experienced in a variety of aspects of thrombosis and hemostasis. Hence, DIC diagnosis is often only entertained when the patient already developed uncontrollable bleeding or multi-organ failure, all of which represent unsalvageable scenarios. Beyond the clinical presentations, the main issue with DIC diagnosis is in relation to coagulation test abnormalities. It is widely believed that in DIC, patients will have prolonged prothrombin time (PT) and partial thromboplastin time (PTT), thrombocytopenia, low fibrinogen, and raised D-dimers. Diagnosis of DIC can be elusive during pregnancy and requires vigilance and knowledge of the physiologic changes during pregnancy. It can be facilitated by using a pregnancy specific DIC score including three components: 1) fibrinogen concentrations; 2) the PT difference - relating to the difference in PT result between the patient's plasma and the laboratory control; and 3) platelet count. At a cutoff of ≥26 points, the pregnancy specific DIC score has 88% sensitivity, 96% specificity, a positive likelihood ratio (LR) of 22, and a negative LR of 0.125. Management of DIC during pregnancy requires a prompt attention to the underlying condition leading to this complication, including the delivery of the patient, and correction of the hemostatic problem that can be guided by point of care testing adjusted for pregnancy.

Download full-text PDF

Source
http://dx.doi.org/10.2147/JBM.S273047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747805PMC
January 2022

Publication Analysis

Top Keywords

dic
11
pregnancy specific
8
specific dic
8
dic patients
8
dic score
8
dic diagnosis
8
pregnancy requires
8
dic pregnancy
8
pregnancy
7
ptt thrombocytopenia
4
prolonged prothrombin
4
prothrombin time
4
time partial
4
partial thromboplastin
4
thromboplastin time
4
time ptt
4
raised d-dimers
4
thrombocytopenia low
4
low fibrinogen
4
fibrinogen raised
4

Keyword Occurance

Similar Publications

Noncoding RNA-Associated Competing Endogenous RNA Networks in Doxorubicin-Induced Cardiotoxicity.

Authors:
Zijun Xiao Shanshan Wei Jie Huang Jiaqin Liu Jian Liu Bikui Zhang Wenqun Li

DNA Cell Biol 2022 May 20. Epub 2022 May 20.

Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.

Accumulating evidence has indicated that noncoding RNAs (ncRNAs) are involved in doxorubicin-induced cardiotoxicity (DIC). However, the ncRNA-associated competing endogenous RNA (ceRNA)-mediated regulatory mechanisms in DIC remain unclear. In this study, we aimed to systematically investigate the alterations in expression levels of long noncoding RNA (lncRNA), circular RNA (circRNA), microRNA (miRNA), and mRNA in a DIC mouse model through deep RNA sequencing (RNA-seq). Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Quantifying the impacts of non-carbonic acid (NCA) stress on dissolved inorganic carbon (DIC) generation in the granitic-hosted watershed, Huangshan UNESCO Global Geopark, China.

Authors:
Yongbin Jiang Min Guo Tangfu Xiao Hongbing Ji

Environ Sci Process Impacts 2022 May 20. Epub 2022 May 20.

Civil and Environmental and Engineering School, University of Science and Technology Beijing, Beijing 100083, China.

To better understand the impacts of non-carbonic acid (NCAs, including sulfuric, nitric and organic acids) stress on DIC generation during chemical weathering, this study investigated the water chemistry and stable isotope composition (C) from a granitic-hosted watershed at Huangshan UNESCO Global Geopark, China. The results show that the dissolved loads of the watershed are dominated by both silicate and carbonate weathering. As a region with greatly distributed acid soil and high occurrence of acid rain, the evolution of the dissolved loads and C show that DIC generation in carbonate dissolution is promoted by HSO, reduced by HNO and little disturbed by organic acids. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

A Novel Central Camera Calibration Method Recording Point-to-Point Distortion for Vision-Based Human Activity Recognition.

Authors:
Ziyi Jin Zhixue Li Tianyuan Gan Zuoming Fu Chongan Zhang Zhongyu He Hong Zhang Peng Wang Jiquan Liu Xuesong Ye

Sensors (Basel) 2022 May 5;22(9). Epub 2022 May 5.

Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, China.

The camera is the main sensor of vison-based human activity recognition, and its high-precision calibration of distortion is an important prerequisite of the task. Current studies have shown that multi-parameter model methods achieve higher accuracy than traditional methods in the process of camera calibration. However, these methods need hundreds or even thousands of images to optimize the camera model, which limits their practical use. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Panoramic/Dual-Surface Digital Image Correlation Measurement Using a Single Camera.

Authors:
Kaiyu Zhu Bing Pan

Sensors (Basel) 2022 Apr 24;22(9). Epub 2022 Apr 24.

Institute of Solid Mechanics, School of Aeronautic Science and Engineering, Beihang University, Beijing 100191, China.

We propose a cost-effective and simple-to-implement mirror-assisted single-camera panoramic digital image correlation (DIC) method for panoramic/dual-surface profile and deformation measurement. Specifically, two planar mirrors and a single camera attached with a four-mirror adapter are used to capture stereo images of the front and rear surfaces of a test object. These stereo images can be processed by regular stereo-DIC to retrieve shape and kinematics fields of each surface. Read More

View Article and Full-Text PDF
April 2022
Similar Publications

Purpura fulminans due to bacteraemia in an unsplectomised immunocompetent adult without primary hypocomplementaemia.

Authors:
Swaminathan Perinkulam Sathyanarayanan Mohammad Ahmed Anthony Hericks

BMJ Case Rep 2022 May 19;15(5). Epub 2022 May 19.

Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota, USA.

Invasive pneumococcal disease occurs in high-risk patient population which includes patients with asplenia and primary hypocomplementaemia. Pneumococcal sepsis can rarely cause disseminated intravascular coagulation (DIC) and intravascular thrombosis of small and medium sized vessels called purpura fulminans which is associated with a high mortality rate. We present the case of an immunocompetent woman in her 50s with an intact spleen who presented with septic shock from bacteraemia. Read More

View Article and Full-Text PDF
May 2022
Similar Publications
}
© 2022 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap