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Front Neuroendocrinol 2022 May 18:100998. Epub 2022 May 18.

Division of Clinical Psychological Intervention, Department of Education and Psychology, Freie Universität Berlin, Schwendenerstraße 27, 14195 Berlin, Germany; Clinical Psychology and Psychotherapy, Department of Psychology, Faculty of Health, HMU Health and Medical University, Olympischer Weg 1, 14471 Potsdam, Germany. Electronic address:

Differential HPA axis function has been proposed to underlie sex-differences in mental disorders; however, the impact of fluctuating sex hormones across the menstrual cycle on HPA axis activity is still unclear. This meta-analysis investigated basal cortisol concentrations as a marker for HPA axis activity across the menstrual cycle. Through a systematic literature search of five databases, 121 longitudinal studies were included, summarizing data of 2641 healthy, cycling participants between the ages of 18 and 45. Read More

Clin Physiol Funct Imaging 2022 May 21. Epub 2022 May 21.

Department of Physical Therapy, Gachon University, Incheon, Korea.

This study assessed the differences in muscle stiffness of the medial gastrocnemius (MG) and tibialis anterior (TA) muscles at rest and contraction during ovulation and follicular phase (menstruation) in women with regular menstrual cycle. Thirty-four young healthy women (mean age 21.3 ± 1. Read More

J Obstet Gynaecol Res 2022 May 20. Epub 2022 May 20.

Department of Obstetrics and Gynecology, Kochi Health Sciences Center, Kochi City, Japan.

Patients with rheumatoid arthritis may demonstrate fluctuations in arthritis symptoms associated with the menstrual cycle. This is the first case report of successful control of menstrual cycle-related exacerbation of rheumatoid arthritis with a gonadotropin-releasing hormone agonist and add-back therapy. A 49-year-old premenopausal woman experienced recurrent severe arthritis flares despite aggressive immunotherapy. Read More

Cannabis Cannabinoid Res 2022 May 20. Epub 2022 May 20.

Department of Psychiatry and Behavioral Neuroscience, University of Chicago Medical Center, Chicago, Illinois, USA.

This study examined effects of oral delta-9-tetrahydrocannabinol (THC) in women at two phases of the menstrual cycle differing in circulating levels of estrogen (E). Pre-clinical findings indicate that E increases sensitivity to THC and other cannabinoids, raising the possibility that higher E may be a risk factor for adverse responses to THC in women. We examined subjective and behavioral responses to THC (7. Read More

Cureus 2022 Apr 16;14(4):e24179. Epub 2022 Apr 16.

Physiology, All India Institute of Medical Sciences, Kalyani, Kalyani, IND.

Background and objectives Type 2 Diabetes mellitus (T2DM) is a heterogeneous group of metabolic disorders with variable degrees of insulin resistance and altered glucose metabolism. Increased attention in studying the role of gonadal hormones in diabetes is not only due to their relation to insulin sensitivity, and glucose tolerance but also to the gender-specific nature of the prevalence of various diabetic complications. The cyclical change in the hormone level in females will make it necessary to consider the menstrual cycle while analyzing the risk factors for diabetes. Read More