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Int J Pharm 2022 May 21:121846. Epub 2022 May 21.

University of Lille, CNRS, INRAE, Centrale Lille, UMR 8207, UMET - Unité Matériaux et Transformations, F-59000 Lille, France.

New clinical indications for an orphan drug bosentan are prompting the improvement of the drug formulation. Since bosentan is available as monohydrate, the information on its anhydrous form together with the assessment of its glass forming ability is necessary when developing enabling formulations. The aim of this research was, therefore, to analyze the phenomena occurring upon dehydration and amorphization of bosentan. Read More

HardwareX 2021 Oct 2;10:e00228. Epub 2021 Sep 2.

Department of Chemistry, NTNU, Trondheim, Norway.

We report a sensitive, fixed-wavelength, lock-in-based optical detector built from a light-emitting diode, two colour filters, a photodetector, a small number of discrete analogue components, and a low-cost microcontroller development board. We describe the construction, operating principle, use and performance of the optical detector, which may be used for both absorption and fluorescence measurements in either a 10-mm pathlength cuvette or a low-volume (<100 μl) flow-cell. For illustrative purposes the detector is applied here to a cholesterol assay based on the enzyme-mediated conversion of (non-emissive) Amplex Red into the fluorescent dye resorufin, providing a detection limit of 200 nM - some four orders of magnitude lower than the typical concentration of cholesterol in human serum. Read More

Heliyon 2022 May 13;8(5):e09411. Epub 2022 May 13.

School of Chemistry and Chemical Engineering, Nantong University, Nantong, 226019, PR China.

Intracellular pH (pHi) is very essential for the function of cells and organisms. Thus, it is of great scientific and technical significance to develop nanosensors for probing pHi. In this work, nitrogen-doped graphene oxide quantum dots (N-GOQDs) with fluorescent efficiency of 54% are prepared. Read More

ACS Macro Lett 2013 Aug 24;2(8):705-709. Epub 2013 Jul 24.

Fujian Provincial Key Laboratory of Fire Retardant Materials, College of Materials, Xiamen University, Xiamen 361005, P. R. China.

A mechanically active spiropyran (SP) mechanophore is incorporated into the center of poly(-butyl acrylate) (PnBA) block to construct a series of mechanoresponsive polystyrene (PS)-PnBA-SP-PnBA-PS triblock copolymers. Similar mechanical activations of SP occur in all of the copolymers in solution, whereas a unique PS fraction-dependent mechanochromism is observed in the bulk. Effective mechanical activation occurs in the copolymer with a medium PS block length, whereas a very weak color change is observed in the samples bearing low PS fractions and activation appears only in the vicinity of the fracture point in the copolymer bearing long PS blocks. Read More

Neuroscience 2022 May 20. Epub 2022 May 20.

Center for Mind/Brain Sciences - CIMeC, University of Trento, Rovereto, TN, Italy. Electronic address:

Understanding age-related changes in cortical excitability and their relation to cognitive functions will help to improve interventions based on non-invasive brain stimulation that aim to support cognitive function in older adults. Here, we investigate the relationship between cortical excitability, executive function, and underlying neural activity in samples of healthy young and older adults. These participants performed a Simon task during electroencephalogram (EEG) recording. Read More