Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

Incidence of cytomegalovirus infection in seropositive kidney transplant recipients treated with everolimus: A randomized, open-label, multicenter phase 4 trial.

Authors:
Hannah Kaminski Nassim Kamar Olivier Thaunat Nicolas Bouvier Sophie Caillard Isabelle Garrigue Dany Anglicheau Jean-Philippe Rérolle Yannick Le Meur Antoine Durrbach Thomas Bachelet Hélène Savel Roxane Coueron Jonathan Visentin Arnaud Del Bello Isabelle Pellegrin Julie Déchanet-Merville Pierre Merville Rodolphe Thiébaut Lionel Couzi

Am J Transplant 2022 May 19;22(5):1430-1441. Epub 2022 Jan 19.

Department of Nephrology, Transplantation, Dialysis and Apheresis, CHU Bordeaux, Bordeaux, France.

Cytomegalovirus (CMV) persists as the most frequent opportunistic infection among solid organ transplant recipients. This multicenter trial aimed to test whether treatment with everolimus (EVR) could decrease the incidence of CMV DNAemia and disease. We randomized 186 CMV seropositive kidney transplant recipients in a 1:1 ratio to receive EVR or mycophenolic acid (MPA) in association with basiliximab, cyclosporin, and steroids and 87 in each group were analyzed. No universal prophylaxis was administered to either group. The composite primary endpoint was the presence of CMV DNAemia, CMV treatment, graft loss, death, and discontinuation of the study at 6 months posttransplant. In the modified intent-to-treat analysis, 42 (48.3%) and 70 (80.5%) patients in the EVR and MPA groups reached the primary endpoint (OR = 0.21, 95% CI: 0.11-0.43, p < .0001). Fewer patients of the EVR group received treatment for CMV (21.8% vs. 47.1%, p = .0007). EVR was discontinued in 31 (35.6%) patients. Among the 56 patients with ongoing EVR treatment, only 7.4% received treatment for CMV. In conclusion, EVR prevents CMV DNAemia requiring treatment in seropositive recipients as long as it is tolerated and maintained.

Download full-text PDF

 Source
http://dx.doi.org/10.1111/ajt.16946DOI Listing
May 2022

Publication Analysis

Top Keywords

transplant recipients
12
cmv dnaemia
8
seropositive kidney
8
kidney transplant
8
primary endpoint
8
cmv
5
basiliximab cyclosporin
4
composite primary
4
group composite
4
administered group
4
prophylaxis administered
4
universal prophylaxis
4
analyzed universal
4
group analyzed
4
steroids group
4
cyclosporin steroids
4
011-043 p 
4
association basiliximab
4
mpa association
4
incidence cytomegalovirus
4

Keyword Occurance

Similar Publications

Toward continuous improvement of Scientific Registry of Transplant Recipients performance reporting: Advances following 2012 consensus conference and future consensus building for 2022 consensus conference.

Authors:
Ajay K Israni Ryutaro Hirose Dorry L Segev Allyson Hart Cory R Schaffhausen David A Axelrod Bertram L Kasiske Jon J Snyder

Clin Transplant 2022 May 21:e14716. Epub 2022 May 21.

Department of Medicine, Hennepin Healthcare, University of Minnesota, Minneapolis, Minnesota, USA.

The Scientific Registry of Transplant Recipients (SRTR) held a consensus conference in 2012 that examined methods used by SRTR for constructing performance metrics and made recommendations on how to improve program-specific reports. That consensus conference provided 25 recommendations categorized as follows: statistical methods, risk adjustment, and outcomes and data. During the subsequent decade, SRTR has implemented most of these recommendations; these are described in this article along with plans for another consensus conference in 2022. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Feasibility and acceptability of high-intensity interval training and moderate-intensity continuous training in kidney transplant recipients: the PACE-KD study.

Authors:
Roseanne E Billany Alice C Smith Ganisha M Hutchinson Matthew P M Graham-Brown Daniel G D Nixon Nicolette C Bishop

Pilot Feasibility Stud 2022 May 21;8(1):106. Epub 2022 May 21.

School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, LE11 3TU, UK.

Background: Kidney transplant recipients (KTRs) exhibit unique elevated inflammation, impaired immune function, and increased cardiovascular risk. Although exercise reduces cardiovascular risk, there is limited research on this population, particularly surrounding novel high-intensity interval training (HIIT). The purpose of this pilot study was to determine the feasibility and acceptability of HIIT in KTRs. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Effect of pre and post-transplant body mass index on pediatric kidney transplant outcomes.

Authors:
Safaa M Abdelrahman Basma Samir Eman Abobakr Abd Alazem Noha Musa

BMC Pediatr 2022 May 21;22(1):299. Epub 2022 May 21.

Diabetes, Endocrine and Metabolism Pediatric Unit, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt.

Introduction: Kidney transplantation (KT) has been established as an efficient treatment of end stage renal disease (ESRD) with the advantage of allowing the patient to live a nearly healthy life. We aimed to determine whether pre-transplant body mass index (BMI) affects renal allograft function and survival in pediatric KT recipients.

Methods: cross sectional cohort study included 50 post KT recipients (more than 3 years) with an age range of 10 to 15 years, regularly following at the Kidney Transplantation Outpatient Clinic, Cairo University Children's Hospital, were subjected to a detailed history and physical examination, laboratory investigation in the form of fasting blood glucose (FBG),oral glucose tolerance test (OGTT), lipid profile, hemoglobin A1c (HbA1c) and microalbuminuria. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Peer support in patients with hematologic malignancies: a systematic review.

Authors:
Hermioni L Amonoo Lauren E Harnedy Sophie C Staton Regina M Longley Elizabeth Daskalakis Areej El-Jawahri Jeff C Huffman

Bone Marrow Transplant 2022 May 21. Epub 2022 May 21.

Harvard Medical School, Boston, MA, USA.

Background: Peer support has been utilized and associated with clinical outcomes (e.g., improved mood) in patients with solid malignancies. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Biomarker-Based Assessment for Infectious Risk Before and After Heart Transplantation.

Authors:
Athena L Huang Nicholas Hendren Spencer Carter Christian Larsen Sonia Garg Ricardo La Hoz Maryjane Farr

Curr Heart Fail Rep 2022 May 21. Epub 2022 May 21.

Division of Cardiology, University of Texas Southwestern Medical Center, 5959 Harry Hines Jr. Blvd, Dallas, TX, 75235, USA.

Purpose Of Review: Survival outcomes for heart transplant recipients have improved in recent decades, but infection remains a significant cause of morbidity and mortality. In this review, we discuss several biological markers, or biomarkers, that may be used to monitor immunologic status in this patient population.

Recent Findings: While modest, data on the utility of immune biomarkers in heart transplant recipients suggest correlation between low level of immune response and increased infection risk. Read More

View Article and Full-Text PDF
May 2022
Similar Publications
}