Search Our Scientific Publications & Authors

Sci Rep 2022 May 20;12(1):8582. Epub 2022 May 20.

The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, 06030, USA.

The three-dimensional (3D) genome structure plays a fundamental role in gene regulation and cellular functions. Recent studies in 3D genomics inferred the very basic functional chromatin folding structures known as chromatin loops, the long-range chromatin interactions that are mediated by protein factors and dynamically extruded by cohesin. We combined the use of FISH staining of a very short (33 kb) chromatin fragment, interferometric photoactivated localization microscopy (iPALM), and traveling salesman problem-based heuristic loop reconstruction algorithm from an image of the one of the strongest CTCF-mediated chromatin loops in human lymphoblastoid cells. Read More

Hum Brain Mapp 2022 May 7. Epub 2022 May 7.

Smart-Aging Research Center, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.

White matter lesions (WML) commonly occur in older brains and are quantifiable on MRI, often used as a biomarker in Aging research. Although algorithms are regularly proposed that identify these lesions from T2-fluid-attenuated inversion recovery (FLAIR) sequences, none so far can estimate lesions directly from T1-weighted images with acceptable accuracy. Since 3D T1 is a polyvalent and higher-resolution sequence, it could be beneficial to obtain the distribution of WML directly from it. Read More

IEEE Trans Neural Netw Learn Syst 2022 Apr 28;PP. Epub 2022 Apr 28.

Detecting hardware Trojan (HT) from a microscope chip image (MCI) is crucial for many applications, such as financial infrastructure and transport security. It takes an inordinate cost in scanning high-resolution (HR) microscope images for HT detection. It is useful when the chip image is in low-resolution (LR), which can be acquired faster and at a lower cost than its HR counterpart. Read More

Sensors (Basel) 2022 Apr 13;22(8). Epub 2022 Apr 13.

DMMS Lab, Flanders Make, 3001 Leuven, Belgium.

Sparsity-based methods have recently come to the foreground of damage detection applications posing a robust and efficient alternative for traditional approaches. At the same time, low-frequency inspection is known to enable global monitoring with waves propagating over large distances. In this paper, a single sensor complex Group Lasso methodology for the problem of structural defect localization by means of compressive sensing and complex low-frequency response functions is presented. Read More

IEEE Trans Image Process 2022 26;31:3295-3308. Epub 2022 Apr 26.

Inverse imaging covers a wide range of imaging applications, including super-resolution, deblurring, and compressive sensing. We propose a novel scheme to solve such problems by combining duality and the alternating direction method of multipliers (ADMM). In addition to a conventional ADMM process, we introduce a second one that solves the dual problem to find the estimated nontrivial lower bound of the objective function, and the related iteration results are used in turn to guide the primal iterations. Read More