Epidemiological and clinical aspects of immunoglobulin A vasculitis in childhood: a retrospective cohort study.

Authors:

Luciana Breda Ilaria Carbone Isabella Casciato Cristina Gentile Eleonora Agata Grasso Giulia di Donato Francesco Chiarelli Alberto Verrotti

Ital J Pediatr 2021 Dec 15;47(1):237. Epub 2021 Dec 15.

Department of Paediatrics, University of Perugia, Piazza dell'Università 1, Perugia, Italy.

Background: A retrospective study was conducted in order to investigate and describe the characteristics of Immunoglobulin A vasculitis (IgAV), previously known as Henoch-Schӧnlein purpura, in the paediatric population of a community-based healthcare delivery system in the Italian region of Abruzzo.

Methods: This is a population-based retrospective chart review of the diagnosis of IgAV in children ages 0 to 18, admitted to the Department of Paediatrics of Chieti and Pescara between 1 January 2000 and 31 December 2016. All children enrolled presented with clinical symptoms and laboratory findings and met the EULAR/PRINTO/PRES 2008 criteria.

Results: Two-hundred-eight children met the criteria for IgAV, with the highest incidence reported among children below 7-years of age. A correlation with recent infections was found in 64% of the cohort; the onset was more frequently during the winter and fall. Purpura had a diffuse distribution in the majority of patients; joint impairment was the second most frequent symptom (43%), whereas the gastrointestinal tract was involved in 28% of patients.

Conclusions: Hereby, we confirm the relative benignity of IgAV in a cohort of Italian children; with regards to renal involvement, we report a better outcome compared to other studies. However, despite the low rate of renal disease, we observed a wide use of corticosteroids, especially for the treatment of persistent purpura.

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http://dx.doi.org/10.1186/s13052-021-01182-6	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672591	PMC

December 2021

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