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Bone 2022 May 20:116449. Epub 2022 May 20.

Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China. Electronic address:

The nucleotide analog reverse-transcriptase inhibitor, tenofovir disoproxil fumarate (TDF), is widely used to treat hepatitis B virus (HBV) and human immunodeficiency virus infection (HIV). However, long-term TDF usage is associated with an increased incidence of bone loss, osteoporosis, fractures, and other adverse reactions. We investigated the effect of chronic TDF use on bone homeostasis and defect repair in mice. Read More

J Trace Elem Med Biol 2022 May 7;72:126995. Epub 2022 May 7.

Pre-Medical Student, Johns Hopkins University, Baltimore, MD, United States.

Trace elements are recognized as being essential in dentin and bone apatite. The effects of zinc, strontium, magnesium, and iron were discussed in part I. In part II, we evaluated the functional role of copper, manganese, silicon, and lithium on dentin apatite, with critical effects on morphology, crystallinity, and solubility. Read More

Biochem Biophys Res Commun 2022 May 13;615:31-35. Epub 2022 May 13.

Department of Medical Ultrasound, The Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Jiaxing, Zhejiang, 314033, China. Electronic address:

Osteoblast cells tend to metabolize glucose to lactate via aerobic glycolysis during osteogenic differentiation. However, the function of lactate in this process is still elusive. As a newly discovered protein posttranslational modification, lactate-derived histone lactylation has been found to play important roles in gene regulation and have profound effects on diverse biological processes. Read More

Front Immunol 2022 6;13:884024. Epub 2022 May 6.

IRCCS Humanitas Research Hospital, Milan, Italy.

The bone marrow (BM) niche is the spatial structure within the intra-trabecular spaces of spongious bones and of the cavity of long bones where adult haematopoietic stem cells (HSCs) maintain their undifferentiated and cellular self-renewal state through the intervention of vascular and nervous networks, metabolic pathways, transcriptional and epigenetic regulators, and humoral signals. Within the niche, HSCs interact with various cell types such as osteoblasts, endothelial cells, macrophages, and mesenchymal stromal cells (MSCs), which maintain HSCs in a quiescent state or sustain their proliferation, differentiation, and trafficking, depending on body needs. In physiological conditions, the BM niche permits the daily production of all the blood and immune cells and their admittance/ingress/progression into the bloodstream. Read More

Comput Math Methods Med 2022 12;2022:4914727. Epub 2022 May 12.

Department of Joints, Tianjin Hospital, Tianjin University, 300211, China.

Disused osteoporosis is a kind of osteoporosis, a common age-related disease. Neurological disorders are major risk factors for osteoporosis. Though there are many studies on disuse osteoporosis, the genetic mechanisms for the association between glutathione metabolism and ferroptosis in osteoblasts with disuse osteoporosis are still unclear. Read More