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Am J Respir Cell Mol Biol 2022 May 24. Epub 2022 May 24.

University of Colorado, School of Medicine, Department of Medicine, Aurora, Colorado, United States.

We previously identified a novel molecular subtype of idiopathic pulmonary fibrosis (IPF) defined by increased expression of cilium-associated genes, airway mucin gene MUC5B, and KRT5 marker of basal cell airway progenitors. Here we show the association of MUC5B and cilia gene expression in human IPF airway epithelial cells, providing further rationale for examining the role of cilium genes in pathogenesis of IPF. We demonstrate increased multiciliogenesis and changes in motile cilia structure of multiciliated cells both in IPF and bleomycin lung fibrosis model. Read More

J Pathol 2022 May 24. Epub 2022 May 24.

Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

The human lung is a relatively quiescent organ in the normal healthy state but contains stem/progenitor cells that contribute to normal tissue maintenance and either repair or remodeling in response to injury and disease. Maintenance or repair lead to proper restoration of functional lung tissue and maintenance of physiological functions, with remodeling resulting in altered structure and function that is typically associated with disease. Knowledge of cell types contributing to lung tissue maintenance and repair/remodeling have largely relied on mouse models of injury-repair and lineage tracing of local progenitors. Read More

ACS Macro Lett 2013 Oct 4;2(10):944-947. Epub 2013 Oct 4.

Max-Bergmann Zentrum für Biomaterialien (MBZ) am IPF, Hohe Straße 6, 01069 Dresden, Germany.

We present a novel scaling theory to describe the interaction free energy within a compressed polymer-brush bilayer. For semidilute brushes at intermediate and strong compressions, we predict that the interaction free energy scales with distance, , between the grafting surfaces as () ∼ ; i.e. Read More

BMC Pulm Med 2022 May 23;22(1):203. Epub 2022 May 23.

Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.

Background: The serum creatinine/cystatin C (Cr/CysC) ratio has attracted attention as a marker for sarcopenia, but has not been studied in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to confirm the utility of the serum Cr/CysC ratio in predicting sarcopenia and investigate its clinical relevance.

Methods: This cross-sectional pilot study prospectively enrolled patients with stable IPF. Read More

J Forensic Nurs 2022 Apr-Jun 01;18(2):117-123

Author Affiliations:School of Nursing, The University of Texas at Austin.

Background: Intimate partner femicide (IPF) is a severe form of violence perpetrated against women in intimate relationships. The purpose of this integrative literature review was to identify studies of IPF in South Korea.

Methods: A web-based literature search was performed in six databases: PubMed, CINAHL, PsycINFO, MEDLINE, SocINDEX, and RISS (Korean academic online database). Read More