Laryngoscope 2021 Oct 15. Epub 2021 Oct 15.
Department of Otolaryngology, Emory University, Atlanta, Georgia, U.S.A.
J Environ Manage 2021 Dec 3;303:114210. Epub 2021 Dec 3.
College of Environment and Energy, South China University of Technology, Guangzhou Higher Education Mega Center, Guangzhou, 510006, China.
Quickly quantifying the PM or O response to their precursor emission changes is a key point for developing effective control policies. The polynomial function-based response surface model (pf-RSM) can rapidly predict the nonlinear response of PM and O to precursors, but has drawbacks of overload computation and marginal effects (relatively larger prediction errors under strict control scenarios). To improve the performance of pf-RSM, a novel self-adaptive RSM (SA-RSM) was proposed by integrating the machine learning-based stepwise regression for establishing robust models to increase the computational efficiency and the collinearity diagnosis for reducing marginal effects caused by overfitting. Read More
Front Plant Sci 2021 15;12:734641. Epub 2021 Nov 15.
Soil Science and Plant Nutrition, UWA School of Agriculture and Environment, The University of Western Australia, Perth, WA, Australia.
Nutrient type and plant functional group are both important in influencing proliferation of roots or hyphae and their benefit to plant growth in nutritionally heterogeneous environments. However, the studies quantifying relative importance of roots vs. hyphae affecting the plant response to nutrient heterogeneity are lacking. Read More
AAPS J 2021 Dec 3;24(1). Epub 2021 Dec 3.
Roche Pharma Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Grenzacherstrasse 124, CH-4070, Basel, Switzerland.
CD3-bispecific antibodies are a new class of immunotherapeutic drugs against cancer. The pharmacological activity of CD3-bispecifics is typically assessed through in vitro assays of cancer cell lines co-cultured with human peripheral blood mononuclear cells (PBMCs). Assay results depend on experimental conditions such as incubation time and the effector-to-target cell ratio, which can hinder robust quantification of pharmacological activity. Read More
Ear Hear 2021 Nov 23. Epub 2021 Nov 23.
Department of Communication Sciences & Disorders, University of Iowa, Iowa City, Iowa, USA; Department of Integrative Structural and Computational Biology, Scripps Science Institute, La Jolla, California, USA Department of Communication Sciences & Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Department of Mathematics & Statistics, Northern Arizona University, Flagstaff, Arizona, USA Department of Communication Sciences and Disorders, Ohio University, Athens, Ohio, USA Department of Communication Sciences & Disorders, Northern Arizona University, Flagstaff, Arizona, USA Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, USA.
Objectives: About 15% of U.S. adults report speech perception difficulties despite showing normal audiograms. Read More
Neurooncol Adv 2021 Nov 27;3(Suppl 5):v86-v95. Epub 2021 Nov 27.
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Leptomeningeal metastasis (LM) is a devastating complication of cancer with variable clinical presentation and limited benefit from existing treatment options. In this review, we discuss advances in LM diagnostics and therapeutics with the potential to reverse this grim course. Emerging cerebrospinal fluid circulating tumor cell and cell-free tumor DNA analysis technologies will improve diagnosis of LM, while providing crucial genetic information, capturing tumor heterogeneity, and quantifying disease burden. Read More