Eur Heart J 2021 Oct 12. Epub 2021 Oct 12.
Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Trends Cell Biol 2021 Oct 22. Epub 2021 Oct 22.
Institute for Research in Biomedicine (iBiMED) and Department of Medical Sciences, University of Aveiro, Aveiro, Portugal. Electronic address:
Peroxisomes, essential subcellular organelles that fulfill important functions in lipid and reactive oxygen species metabolism, have recently emerged as key players during viral infections. Their importance for the establishment of the cellular antiviral response has been highlighted by numerous reports of specific evasion of peroxisome-dependent signaling by different viruses. Recent data demonstrate that peroxisomes also assume important proviral functions. Read More
Enzymes 2021 23;49:1-37. Epub 2021 Aug 23.
The Rockefeller University, New York, New York, United States. Electronic address:
The ongoing Covid-19 pandemic has spurred research in the biology of the nidovirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Much focus has been on the viral RNA synthesis machinery due to its fundamental role in viral propagation. The central and essential enzyme of the RNA synthesis process, the RNA-dependent RNA polymerase (RdRp), functions in conjunction with a coterie of viral-encoded enzymes that mediate crucial nucleic acid transactions. Read More
Viruses 2021 Oct 19;13(10). Epub 2021 Oct 19.
Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, Cidade Universitária, São Paulo 05508-090, SP, Brazil.
The Zika virus (ZIKV) has shown a promising oncolytic effect against embryonal CNS tumors. However, studies on the effect of different administration routes and the ideal viral load in preclinical models are highly relevant aiming for treatment safety and efficiency. Here, we investigated the effect and effectiveness of different routes of administration, and the number of ZIKV injections on tumor tropism, destruction, and side effects. Read More
Br J Sociol 2021 Oct 25. Epub 2021 Oct 25.
Department of Sociology, University of Toronto, Toronto, Ontario, Canada.
A sizeable portion of parents say they lack time with children-an important social problem given that time strains link to parental well-being. Extending perspectives on the demands and rewards of parenting beyond the individual level, we provide a contextual-level window onto mothers' and fathers' time strains. Based on data from the European Quality of Life Survey 2016/17 (n = 5,898), we analyze whether parents feel they spend enough time caring for their children using multilevel models. Read More
Adv Sci (Weinh) 2021 Oct 24:e2101837. Epub 2021 Oct 24.
Complex Tissue Regeneration Department, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Universiteitssingel 40, Maastricht, 6229ER, The Netherlands.
Neurovascular disorders, which involve the vascular and nervous systems, are common. Research on such disorders usually focuses on either vascular or nervous components, without looking at how they interact. Adopting a neurovascular perspective is essential to improve current treatments. Read More