Can J Physiol Pharmacol 2021 Mar 9;99(3):348. Epub 2021 Mar 9.
Department of Cardiology, Tongji Hospital of Tongji University, Shanghai 200003, People's Republic of China.
Front Immunol 2021 30;12:758451. Epub 2021 Sep 30.
Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Macrophages promote early host responses to infection by releasing pro-inflammatory cytokines, and they are crucial to combat amoebiasis, a disease affecting millions of people worldwide. Macrophages elicit pro-inflammatory responses following direct cell/cell interaction of , inducing NLRP3 inflammasome activation with high-output IL-1β/IL-18 secretion. Here, we found that trophozoites could upregulate peroxiredoxins (Prx) expression and abundantly secrete Prxs when encountering host cells. Read More
Front Endocrinol (Lausanne) 2021 7;12:718235. Epub 2021 Sep 7.
Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, United States.
Oxidative stress is hypothesized to play a role in pancreatic β-cell damage, potentially contributing to β-cell dysfunction and death in both type 1 and type 2 diabetes. Oxidative stress arises when naturally occurring reactive oxygen species (ROS) are produced at levels that overwhelm the antioxidant capacity of the cell. ROS, including superoxide and hydrogen peroxide, are primarily produced by electron leak during mitochondrial oxidative metabolism. Read More
Int J Mol Sci 2021 Aug 30;22(17). Epub 2021 Aug 30.
BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu 41566, Korea.
Peroxiredoxins (PRDXs) are expressed in the ovary and during ovulation. PRDX1 activity related to the immuno-like response during ovulation is unknown. We investigated the roles of on TLR4 and ERK1/2 signaling from the ovulated cumulus-oocyte complex (COC) using -knockout (K/O) and wild-type (WT) mice. Read More
Evid Based Complement Alternat Med 2021 19;2021:1967158. Epub 2021 Aug 19.
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi 030801, China.
The scorpions, named , commonly called Quanxie () in Chinese, have been widely used as one of the animal medicines for more than 1,000 years because of the strong toxicity of their venoms. Meanwhile, scorpions are sexually dimorphic in appearance, and many exhibit traits associated with sex-biased gene expression, including maternal care, mating competition, female mating choices, ecology, and even venom composition and lethality. This study aims to explore the differences in composition of the venom of scorpions of different sex using the method of transcriptomics. Read More