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J Stomatol Oral Maxillofac Surg 2022 May 24. Epub 2022 May 24.

Univ. Lille, CHU Lille, Department of Oral and Maxillofacial Surgery, Roger Salengro Hospital, F-59000 Lille, France.

Introduction: Although most localized odontogenic infections can be managed successfully without complications, some can cause extensive morbidity through the onset of cervicofacial cellulitis. The management of these more severe infections generally requires emergency treatment, including surgical treatment under general anesthesia, and prolonged length of hospital stay.

Material & Methods: In this work, we assessed the impact of the provision of a hospital-based dental emergency department on the regional incidence of severe odontogenic cellulitis in a socioeconomically precarious region. Read More

Nanomedicine 2022 May 24:102570. Epub 2022 May 24.

Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs, School of Pharmacy, Yantai University, Yantai 264005,PR China. Electronic address:

Ischemic stroke is an acute and severe neurological disease, resulting in disability and death. The poor drug delivery to cerebral ischemic regions is a key challenge of ischemic stroke treatment. Inspired by the ability of Macrophage membranes to cross the blood-brain barrier, We prepared amphiphilic nanoparticles ([email protected]) by linking Angelica polysaccharide (APS) and Ethyl ferulate (EF) using oxalate bond (OL) as the linker arm, with an inner core encapsulated with Tetramethylpyrazine (TMP), and finally using macrophage membrane camouflage ([email protected]). Read More

Nanomedicine 2022 May 24:102571. Epub 2022 May 24.

Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, United States; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address:

Synthetic high-density lipoprotein (sHDL) and rapamycin (Rap) have both been shown to be potential treatments for age-related macular degeneration (AMD). The low aqueous solubility of Rap, however, limits its therapeutic utility. Here we used an Apolipoprotein A-I mimetic peptide and phospholipid-based sHDL for the intravitreal delivery of Rap. Read More

Semin Cancer Biol 2022 May 24. Epub 2022 May 24.

Cancer Center and Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshedong Str., Zhengzhou, 450052, China. Electronic address:

Epigenetic regulation by microRNAs (miRs) demonstrated a promising therapeutic potential of these molecules to regulate genetic activity in different cancers, including colorectal cancers (CRCs). The RNA-based therapy does not change genetic codes in tumor cells but can silence oncogenes and/or reactivate inhibited tumor suppressor genes. In many cancers, specific miRs were shown to promote or stop tumor progression. Read More

Sci Total Environ 2022 May 24:156212. Epub 2022 May 24.

Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

Nanotechnology-driven solutions have almost touched every aspect of life, such as therapeutics, cosmetics, agriculture, and the environment. Physical and chemical methods for the synthesis of nanoparticles involve hazardous reaction conditions and toxic reducing as well as stabilizing agents. Hence, environmentally benign green routes are preferred to synthesize nanoparticles with tunable size and shape. Read More