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Genes (Basel) 2022 Apr 27;13(5). Epub 2022 Apr 27.

Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350108, China.

Humantenine, an alkaloid isolated from the medicinal herb (Gardner & Chapm.) Benth., has been reported to induce intestinal irritation, but the underlying toxicological mechanisms remain unclear. Read More

Rapid Commun Mass Spectrom 2022 Jun;36(12):e9302

College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China.

Rationale: Rankinidine belongs to the humantenine-type alkaloids isolated from Gelsemium. Currently, the mechanism behind the toxicity differences of rankinidine has not been explained. In this study, our purpose was to elucidate the major in vitro metabolic pathways of rankinidine and to compare the formation of metabolites of rankinidine in human (HLMs), rat (RLMs), goat (GLMs) and pig (PLMs) liver microsomes. Read More

Curr Drug Metab 2021 ;22(10):795-7801

College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, Hunan, China.

Background: Gelsemium elegans Benth (G. elegans) is a well-known toxic plant. Alkaloids are the main active components of G. Read More

J Nat Prod 2015 Jul 23;78(7):1511-7. Epub 2015 Jun 23.

†Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Mengla, Yunnan 666303, People's Republic of China.

Nine new alkaloids of the koumine (1-4), humantenine (5-7), and yohimbane (8, 9) types as well as 12 known analogues were isolated from the leaves and vine stems of Gelsemium elegans. Compound 1 is the first N-4-demethyl alkaloid of the koumine type, compound 7 is the first nor-humantenine alkaloid, and compounds 8 and 9 are the first N-1-oxide and the first seco-E-ring alkaloids, respectively, of the yohimbane type. Compounds 1 and 7 exhibited moderate cytotoxicity against five human tumor cell lines with IC50 values in the range 4. Read More

J Ethnopharmacol 2015 May 10;166:66-73. Epub 2015 Mar 10.

College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China.

Ethnopharmacological Relevance: Gelsemium elegans (GE), widely distributed in East Asia, South East Asia and Northern America, is a kind of well-known toxic plant throughout the world. Yet it has been used as a Chinese folk medicine for treatment of malignant tumors, pain, rheumatic arthritis, psoriasis and immune function.

Aim Of The Study: The present study was to investigate the potential inhibitory effects of G. Read More