Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

LncRNA PCGsEM1 Contributes to the Proliferation, Migration and Invasion of Non-small Cell Lung Cancer Cells via acting as a Sponge for miR-152-3p.

Authors:
Jianhui Huang Jian Lou Xueni Liu Yanru Xie

Curr Pharm Des 2021 ;27(46):4663-4670

Department of Medical Oncology, Lishui Municipal Central Hospital, Lishui 323000, Zhejiang, China.

Background: Long non-coding RNAs (lncRNAs) have been reported to play important roles in cellular biological function. Aberrant expression of lncRNAs has been found to be related to the progression of various diseases. LncRNA prostate cancer gene expression marker 1 (PCGEM1) has been demonstrated to be involved in the initiation and progression of human cancers. However, to date, the clinical and functional significance of PCGEM1 expression in NSCLC progression remains unknown.

Methods: The expression of LncRNA PCGEM1 and miR-152-3p in NSCLC tissues and cells was analyzed using quantitative real-time RT-PCR. Experiments using NSCLC cells were conducted to explore the influence of PCGEM1 on tumor cell proliferation, migration and invasion.

Results: Increased expression of PCGEM1 was observed in NSCLC tissues and cells compared with the corresponding controls (all P < 0.001). PCGEM1 expression was associated with NSCLC patients' lymph node metastasis and TNM stage (all P < 0.05), and the knockdown of PCGEM1 in NSCLC cells led to inhibited cell proliferation, migration and invasion. The further luciferase reporter assay and expression results showed that miR-152-3p might be a target gene of PCGEM1 and mediate the effects of PCGEM1 on cell proliferation, migration and invasion in NSCLC.

Conclusion: Thus, the findings from the present study indicate that the NSCLC patients have significantly increased PCGEM1 and decreased miR-152-3p expression and that the knockdown of PCGEM1 may inhibit NSCLC cell proliferation, migration and invasion by sponging miR-152-3p. The PCGEM1/miR-152-3p axis may provide novel therapeutic targets for NSCLC treatment.

Download full-text PDF

 Source
http://dx.doi.org/10.2174/1381612827666210827104828DOI Listing
March 2022

Publication Analysis

Top Keywords

proliferation migration
20
migration invasion
16
cell proliferation
16
pcgem1
11
nsclc
9
nsclc cells
8
knockdown pcgem1
8
pcgem1 expression
8
expression
8
tissues cells
8
nsclc tissues
8
migration
5
cell
5
proliferation
5
cells
5
mir-152-3p
5
expression associated
4
cells compared
4
compared corresponding
4
corresponding controls
4

Keyword Occurance

Similar Publications

KMT2B promotes the growth of renal cell carcinoma via upregulation of SNHG12 expression and promotion of CEP55 transcription.

Authors:
Jia-Fu Feng Jun Wang Gang Xie Yao-Dong Wang Xiao-Han Li Wen-Yu Yang Yu-Wei Yang Bin Zhang

Cancer Cell Int 2022 May 21;22(1):197. Epub 2022 May 21.

NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 12 Changjia Lane, Jingzhong Street, Mianyang, 621000, People's Republic of China.

Background: This study aims to clarify the mechanistic action of long non-coding RNA (lncRNA) SNHG12 in the development of renal cell carcinoma (RCC), which may be associated with promoter methylation modification by KMT2B and the regulation of the E2F1/CEP55 axis.

Methods: TCGA and GEO databases were used to predict the involvement of SNHG12 in RCC. Knockdown of SNHG12/E2F1/CEP55 was performed. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

SHED-derived exosomes promote LPS-induced wound healing with less itching by stimulating macrophage autophagy.

Authors:
Yunyi Xie Le Yu Zhilan Cheng Yingying Peng Zeyuan Cao Beichen Chen Yihong Duan Yan Wang

J Nanobiotechnology 2022 May 21;20(1):239. Epub 2022 May 21.

Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, 56 Lingyuanxi Road, Guangzhou, 510055, People's Republic of China.

High-quality cutaneous wound healing is associated with rapid wound closure and a comfortable healing process. Currently, exosomes derived from mesenchymal stem cells displayed a prominent therapeutic effect on skin wound closure. But the therapeutic approaches for wound itching are very limited in clinical. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Calcium-binding protein S100P is a new target gene of MACC1, drives colorectal cancer metastasis and serves as a prognostic biomarker.

Authors:
Felicitas Schmid Mathias Dahlmann Hanna Röhrich Dennis Kobelt Jens Hoffmann Susen Burock Wolfgang Walther Ulrike Stein

Br J Cancer 2022 May 21. Epub 2022 May 21.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Background: The metastasis inducing gene MACC1 is a prognostic and predictive biomarker for metastasis in several cancers. Its mechanism of inducing metastasis includes the transcriptional control of other cancer-related target genes. Here, we investigate the interplay with the metastasis driver S100P in CRC progression. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Noncoding RNA actions through IGFs and IGF binding proteins in cancer.

Authors:
Aidan Kerr Robert C Baxter

Oncogene 2022 May 21. Epub 2022 May 21.

University of Sydney, Faculty of Medicine and Health, Kolling Institute, Royal North Shore Hospital, St Leonards, Sydney, NSW, 2065, Australia.

The insulin-like growth factors (IGFs) and their regulatory proteins-IGF receptors and binding proteins-are strongly implicated in cancer progression and modulate cell survival and proliferation, migration, angiogenesis and metastasis. By regulating the bioavailability of the type-1 IGF receptor (IGF1R) ligands, IGF-1 and IGF-2, the IGF binding proteins (IGFBP-1 to -6) play essential roles in cancer progression. IGFBPs also influence cell communications through pathways that are independent of IGF1R activation. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Bioactive xanthones, benzophenones and biphenyls from mangosteen root with potential anti-migration against hepatocellular carcinoma cells.

Authors:
Siwattra Choodej Kedkarn Koopklang Achara Raksat Natthaya Chuaypen Khanitha Pudhom

Sci Rep 2022 May 21;12(1):8605. Epub 2022 May 21.

Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.

Liver cancer refers primarily to hepatocellular carcinoma (HCC) accounting for over 90% of cases and is the highest incidence in men in Thailand. Over the past decades, the incidence of HCC dramatically increased with a strong rise of mortality rates. Garcinia mangostana, "Queen of Fruit" of Thailand, is known as a rich source of xanthones with potent cytotoxic properties against various cancer cells. Read More

View Article and Full-Text PDF
May 2022
Similar Publications
}