Radiology 2021 Oct 3;301(1):45. Epub 2021 Aug 3.
From the Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, No. 25 TaiPing St, Jiangyang District, Luzhou 646000, People's Republic of China; and Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, People's Republic of China.
J Nucl Med 2021 Sep 16. Epub 2021 Sep 16.
Medical University of Vienna, Austria.
Increased expression of fibroblast activating protein (FAP) in fibrous caps may contribute to progression of atherosclerotic plaques. Forty-one patients who underwent gallium-68-conjugated quinoline-based FAP inhibitor (Ga-FAPI-04) PET/CT for non-cardiovascular indications were retrospectively analyzed. Correlations were assessed between the uptake of Ga-FAPI-04 in large arterial walls (SUV and target-to-background ratio, TBR) and degree of calcification and cardiovascular risk factors. Read More
Rheumatology (Oxford) 2021 Aug 27. Epub 2021 Aug 27.
Department of Experimental Rheumatology, Radboudumc, Nijmegen, The Netherlands.
Objective: Activated synovial fibroblasts are key effector cells in rheumatoid arthritis (RA). Selectively depleting these based upon their expression of fibroblast activation protein (FAP) is an attractive therapeutic approach. Here we introduce FAP imaging of inflamed joints using [68Ga]Ga-FAPI-04 in an RA patient, and aim to assess feasibility of anti-FAP targeted photodynamic therapy (FAP-tPDT) ex vivo using 28H1-IRDye700DX on RA synovial explants. Read More
Ann Nucl Med 2021 Aug 26. Epub 2021 Aug 26.
Department of Nuclear Medicine, Gaziantep University, 27310, Sahinbey, Gaziantep, Turkey.
Purpose: We compared the ability of Ga-FAPI PET//CT with FDG PET/CT imaging techniques to detect additional lesions in breast cancer patients that may affect further chemotherapy options.Methods: A total of 48 patients with breast cancer underwent concurrent Ga-FAPI-04 and FDG PET/CT regardless of whether they had received chemotherapy or not in the last month before imaging. Both modalities were compared according to various parameters: clinical/pathological features, number of lesions detected, activity uptake (SUV), and the effect on the evaluation of response to treatment in the post-chemotherapy group. Read More
Ann Nucl Med 2021 Aug 23. Epub 2021 Aug 23.
Department of Nuclear Medicine, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian, China.
Objectives: The objective of the study was to characterize benign lesions showing increased Ga-FAPI-04 uptake on FAPI PET/CT.Methods: We retrospectively reviewed 182 patients with suspected various cancers who were performed Ga-FAPI-04 PET/CT imaging from August 2020 to December 2020. The diagnoses of the benign lesions were made by the CT findings (CT), other imaging information (OII) (contrast enhance CT, FDG PET, ultrasound, MRI or others), clinical information (CI) (medical history, laboratory examination, symptom, physical sign and follow-up information) or histological biopsy (HB). Read More
Nucl Med Mol Imaging 2021 Aug 22;55(4):194-198. Epub 2021 Jun 22.
Department of Cardiology, MIOT International, Chennai, India.
Recent studies using Ga-68-labeled fibroblast activation protein inhibitors (FAPI) PET have shown strong association between focal uptake of FAPI in myocardium and presence of coronary artery disease. We present an interesting case of a 76-year-old female with breast cancer with incidental uptake on FAPI PET in apex and septal wall of left ventricle myocardium correlating with findings of ischemia on dobutamine stress myocardial perfusion imaging and anatomical stenosis on coronary angiography. Read More