J Clin Anesth 2021 Jul 28;75:110468. Epub 2021 Jul 28.
Department of Anesthesiology and Intensive Care Medicine, University Hospital of Besancon, Besancon, France. Electronic address:
J Arthroplasty 2021 Aug 27. Epub 2021 Aug 27.
'Sir John Charnley' Hip Surgery Unit, Institute of Orthopaedics 'Carlos E. Ottolenghi', Italian Hospital of Buenos Aires, Buenos Aires, Argentina.
Background: The ideal dose of intravenous glucocorticoids to control pain in total hip arthroplasty (THA) remains unclear. This randomized controlled trial compared postoperative pain and tramadol requirement in patients undergoing unilateral primary THA who received one versus two perioperative doses of dexamethasone.Methods: Patients consented to undergo blinded, simple randomization to either one (at anesthetic induction [1D-group]: 54 patients) or two (with an additional dose 8 hours after surgery [2D-group]: 61 patients) perioperative doses of 8-mg intravenous dexamethasone. Read More
Semin Dial 2021 Sep 18. Epub 2021 Sep 18.
Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Nephrology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Vancomycin is one of the drugs used in the peritonitis treatment regimen of peritoneal dialysis patients. Intraperitoneal route is generally preferred to provide rapid elimination of infective agents. Systemic toxicities of certain drugs after intraperitoneal administration are not very clear. Read More
J Clin Anesth 2021 Sep 14;75:110518. Epub 2021 Sep 14.
Department of Anaesthesia and Perioperative Medicine, Sunshine Coast University Hospital, Birtinya, Australia. Electronic address:
J Pharmacol Exp Ther 2021 Sep 16;378(3):244-250. Epub 2021 Jun 16.
Instituto de Investigaciones Biomédicas, (I.N.P.O, A.E., M.G.V., P.P., B.B., G.F., E.L.S.C.), Facultad de Químicas (H.J.-C.), Universidad Nacional Autónoma de México, Mexico City, Mexico; Research Group Immunophysiology, Division of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps Universität, Marburg, Germany (H.B.); and Departament of Parasitology, Instituto de Diagnóstico y Referencia Epidemiológicos, Secretaría de Salud, Mexico City, Mexico (G.M.)
Neuroinflammation (NI) is an important physiologic process which promotes the tissue repair and homeostatic maintenance in the central nervous system after different types of insults. However, when it is exacerbated and sustained in time, NI plays a critical role in the pathogenesis of different neurologic diseases. The high systemic doses required for brain-specific targeting lead to severe undesirable effects. Read More
JAMA Oncol 2021 Sep 16. Epub 2021 Sep 16.
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Importance: High-risk smoldering myeloma has a 5-year risk of progression to symptomatic multiple myeloma of approximately 75%. Treatment with lenalidomide decreases the risk of progression; however, novel triplet regimens are superior, and earlier disease may be more treatment sensitive.Objective: To evaluate the use of carfilzomib, lenalidomide, and dexamethasone (KRd) with lenalidomide maintenance therapy as early intervention in high-risk smoldering myeloma and to determine the rates of minimal residual disease (MRD)-negative complete response (CR). Read More