Thromb Res 2021 Oct 2;206:1-4. Epub 2021 Jul 2.
CESP-Center for Public Health Research, University of Milan Bicocca, Monza, Italy; IRCCS Multimedica, Sesto San Giovanni, Italy. Electronic address:
Thyroid 2021 Sep 19. Epub 2021 Sep 19.
Istituto Nazionale Tumori IRCCS Fondazione Pascale, 18730, Struttura Complessa Chirurgia Oncologica della Tiroide, Napoli, Campania, Italy;
Background: The role of minimal extrathyroidal extension (mETE) as a risk factor for persistent papillary thyroid carcinoma (PTC) is still debated. The aim of this study was to assess the clinical impact of mETE as a predictor of worse initial treatment response in PTC patients and to verify the impact of radioiodine therapy after surgery in patients with mETE.Methods: We reviewed all records in the Italian Thyroid Cancer Observatory (ITCO) database and selected 2237 consecutive patients with PTC who satisfied the inclusion criteria (PTC with no lymph node metastases and at least 1 year of follow-up). Read More
Clin Cancer Res 2021 Aug 31. Epub 2021 Aug 31.
Department of Pathology, Yale School of Medicine
Purpose: The companion diagnostic test for trastuzumab has not changed much in the last 25 years. We used high-plex digital spatial profiling to identify biomarkers besides HER2 that can help predict response to trastuzumab in HER2-positive breast cancer.Experimental Design: Fifty-eight protein targets were measured in three different molecularly defined compartments by the NanoString® GeoMx® Digital Spatial Profiler (DSP) in a tissue microarray containing 151 breast cancer patients that received adjuvant trastuzumab as part of the HeCOG 10/05 clinical trial. Read More
Front Immunol 2021;12:704110. Epub 2021 Aug 10.
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Patients diagnosed with malignancy, neurological and immunological disorders, , fragile patients, have been excluded from COVID-19 vaccine trials. However, this population may present immune response abnormalities, and relative reduced vaccine responsiveness. Here we review the limited current evidence on the immune responses to vaccination of patients with different underlying diseases. Read More
Aging Clin Exp Res 2021 Aug 20. Epub 2021 Aug 20.
School of Medicine and Surgery, Università Degli Studi Milano-Bicocca and Acute Geriatric Unit, San Gerardo Hospital Monza, Milan, Italy.
Introduction: Delirium and sarcopenia are common, although underdiagnosed, geriatric syndromes. Several pathological mechanisms can link delirium and low skeletal muscle mass, but few studies have investigated their association. We aimed to investigate (1) the association between delirium and low skeletal muscle mass and (2) the possible role of calf circumference mass in finding cases with delirium. Read More
Med Oncol 2021 Aug 3;38(9):107. Epub 2021 Aug 3.
Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Via Giacomo Venezian, 1, 23100, Milano, Italy.
The purpose of this study was to evaluate the impact of breast size on acute and late side effects in breast cancer (BC) patients treated with hypofractionated radiotherapy (Hypo-RT). In this study we analyzed patients over 50 years with a diagnosis of early BC, candidate for Hypo-RT after conservative surgery. Acute and late skin toxicities were evaluated in accordance with the RTOG scale. Read More