J Am Acad Dermatol 2021 Jul 24. Epub 2021 Jul 24.
Division of Dermatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:
Diseases 2021 Sep 20;9(3). Epub 2021 Sep 20.
Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires 1007, Argentina.
This brief review was written to provide a perspective on the flurry of reports suggesting that melatonin can be an important add-on therapy for COVID-19. Despite the passage of more than 60 years since its discovery and much evidence representing the contrary, there has been great reluctance to conceive melatonin as anything other than a hormone. Many other body chemicals are known to have multiple roles. Read More
Diabetes Metab Syndr 2021 Sep 16;15(6):102282. Epub 2021 Sep 16.
Department of Diabetes & Endocrinology, G.D Hospital & Diabetes Institute, Kolkata, India.
Background And Aims: We aimed to know whether SGLT-2 inhibitors (SGLT-2I) exhibit similar cardiovascular (CV) benefit in patients having reduced ejection fraction heart failure (HFrEF) with varying degree of glycemia.Method: We meta-analyzed the trial-level hazard ratio and 95% confidence interval of randomized trials that reported the CV outcomes stratified in to three subgroups of normoglycemia, prediabetes and diabetes.Results: This meta-analysis found a significant and similar CV risk reduction in patients with HFrEF without any significant interaction between three subgroups (P = 0. Read More
Thromb Res 2021 Sep 21;207:67-74. Epub 2021 Sep 21.
Santé Publique France, Saint-Maurice 94, France.
Introduction: The onset of the COVID-19 pandemic and the first national lockdown implemented might have disrupted the epidemiology of deep venous thrombosis (DVT) and pulmonary embolism (PE). This study aimed to analyze time trends in patients hospitalized for DVT and PE in France and related in-patient and 90-day post-admission mortality rates.Materials And Methods: All patients hospitalized in France for DVT or PE between January and September (weeks 1-40) for each year from 2017 to 2020, were selected. Read More
Am J Infect Control 2021 Sep 22. Epub 2021 Sep 22.
Univ. Grenoble Alpes, CNRS, MESP TIM-C, UMR 5525, Grenoble Alpes University Hospital, Infection Control Unit, CHU Grenoble CS 10217 38043 GRENOBLE Cedex 9, France. Electronic address:
Purpose: Large inrush of patients through Emergency Department during influenza season can be dramatic.The purpose of this study was to evaluate the impact of an emergency preventive strategy, namely admission of patients with influenza in multiple-bed room with patients free from influenza, on the occurrence of hospital-acquired influenza (HAI).Methods: When a patient with an influenza RT-PCR diagnosis was hospitalized in a multiple-bed room, the emergency preventive strategy was applied: selection of non-immunocompromised neighbor, implementation of physical barriers (rigid screen pulled between beds, surgical mask for healthcare workers and visitors), preemptive Oseltamivir therapy for the neighbor. Read More
Hospital das Clínicas, University of São Paulo, Rua, Av. Dr. Enéas Carvalho de Aguiar, 255 - Cerqueira César, São Paulo, 05403-000, Brazil.
Background: The impact of COVID-19 on healthcare- associated infections (HCAI) caused by multidrug-resistant (MDR) bacteria that contribute to higher mortality is a growing area of study METHODS: This retrospective observational study compares the incidence density (ID) of HCAI caused by MDR bacteria (CRE, CRAB, CRP, MRSA and VRE) pre-COVID (2017-2019) and during the COVID-19 pandemic (2020) in overall hospitalized patients and in intensive care (ICU) units.Results: We identified 8,869 HCAI, of which 2,641 (29.7%) were caused by bacterial MDR, and 1,257 (14. Read More