Pak J Med Sci 2021 Jul-Aug;37(4):931-932
Øyvind Bleie MD, PhD, FESC Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Curr Opin Hematol 2021 Sep 15. Epub 2021 Sep 15.
Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Pediatric Hematopoietic Cellular Therapy Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Pediatric Hematology, Emory University, Atlanta, Georgia Boston Children's/Dana Farber Cancer and Blood Disorders Center, Pediatric Hematopoietic Cellular Therapies, Boston, Massachusetts, USA.
Purpose Of Review: Transplant-associated thrombotic microangiopathy (TA-TMA) is a complication that can occur in both allogeneic and autologous haematopoietic cellular therapy (HCT) recipients and is associated with significant morbidity and mortality. Although TA-TMA is a complex disease, there is emerging evidence that complement activation and endothelial dysfunction play a key role in the pathophysiology of the disease. The use of eculizumab has improved survival in patients with high risk and severe disease, but mortality rates in treated patients still exceed 30%, highlighting the need for novel approaches. Read More
Radiol Imaging Cancer 2021 Sep;3(5):e219019
J Am Heart Assoc 2021 Sep 17:e019282. Epub 2021 Sep 17.
Division of Cardiology Department of Internal Medicine St. Marianna University School of Medicine Kanagawa Japan.
Background Current guidelines recommend at least 6 months of antithrombotic therapy and antibiotic prophylaxis after septal-occluding device deployment in transcatheter closure of atrial septal defect. It has been estimated that it takes ≈6 months for complete neo-endothelialization; however, neo-endothelialization has not previously been assessed in vivo in humans. Methods and Results The neointimal coverage of septal occluder devices was evaluated 6 months after implantation in 15 patients by angioscopy from the right atrium. Read More
J Am Coll Cardiol 2021 Sep;78(12):1266-1274
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA; Cardiology Division, Kyung Hee University, Seoul, South Korea. Electronic address:
Plaque erosion, a distinct histopathological and clinical entity, accounts for over 30% of acute coronary syndromes (ACS). Optical coherence tomography allows in vivo diagnosis of plaque erosion. Local flow perturbation with activation of Toll-like receptor 2 and CD8 T cells and subsequent desquamation of endothelium and neutrophil extracellular trap formation contribute to mechanisms of plaque erosion. Read More
Clin Otolaryngol 2021 Sep 16. Epub 2021 Sep 16.
Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, the University of Tokyo, Tokyo, Japan.
Objective: Although various guidelines have been established for the management of antithrombotic therapy during surgical treatments, surgical tracheostomy (ST) under continued antithrombotic therapy (CAT) remains a challenge. We investigated the risk factors for complications after ST by focusing on CAT use during ST.Method: Patients' medical records from 2009 to 2020 were reviewed in this retrospective study. Read More