J Rheumatol 2021 03;48(3):311-313
I.J. Berg, MD, PhD, Consultant Rheumatologist; S.A. Provan, MD, PhD Associate Professor, Consultant Rheumatologist, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Res Vet Sci 2021 Sep 8;140:212-220. Epub 2021 Sep 8.
Department of Internal Medicine, University of São Paulo, School of Veterinary Medicine and Animal Science, Av. Prof. Dr. Orlando Marques de Paiva, 87, Cidade Universitária, 05508270 São Paulo, Brazil. Electronic address:
The synovial membrane (SM) presents itself with distinctive characteristics during arthroscopic procedures in cases of osteoarthritis (OA) as well as osteochondritis dissecans (OCD) in horses. Most of the arthroscopic findings of the SM are limited to a description of a nonspecific inflammation state. In the present study, the macroscopic and histological aspects of the SM in OA and OCD horses were compared to those of healthy horses. Read More
Tissue Cell 2021 Aug 10;73:101621. Epub 2021 Aug 10.
Department of Joint Orthopedics, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jianye District, Nanjing City, Jiangsu Province, 210017, China. Electronic address:
The effects of anti-inflammatory drug gossypol on osteoarthritis (OA) treatment were discussed in this paper. After identified using toluidine blue and immunofluorescence staining of type II collagen, chondrocytes from OA patients were treated with interleukin-1β (IL-1β), gossypol, and overexpressed connexin43 (CX43). In treated chondrocytes, according to MTT assay and flow cytometry, gossypol increased viability and reduced apoptosis of IL-1β induced chondrocytes. Read More
Crit Care Med 2021 Sep 16. Epub 2021 Sep 16.
Pathophysiology of Injury-Induced Immunosuppression (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux), Joint Research Unit HCL-bioMérieux, Immunology Laboratory & Anesthesia and Critical Care Medicine Department, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France. BIOASTER, Lyon, France. Sanofi Pasteur, Marcy l'Etoile, France. GSK, GSK Medicines Research Centre, Stevenage, United Kingdom. Laboratoire de Biochimie (LBC), ESPCI Paris, PSL Université, CNRS UMR8231, Paris, France.
Objectives: The host response plays a central role in the pathophysiology of sepsis and severe injuries. So far, no study has comprehensively described the overtime changes of the injury-induced immune profile in a large cohort of critically ill patients with different etiologies.Design: Prospective observational cohort study. Read More
J Orthop Res 2021 Sep 17. Epub 2021 Sep 17.
Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, Yliopistonranta 1, FI, 70210, Kuopio, Finland.
Excessive tissue deformation near cartilage lesions and acute inflammation within the knee joint after anterior cruciate ligament (ACL) rupture and reconstruction surgery accelerate the loss of fixed charge density (FCD) and subsequent cartilage tissue degeneration. Here, we show how biomechanical and biochemical degradation pathways can predict FCD loss using a patient-specific finite element model of an ACL reconstructed knee joint exhibiting a chondral lesion. Biomechanical degradation was based on the excessive maximum shear strains that may result in cell apoptosis, while biochemical degradation was driven by the diffusion of pro-inflammatory cytokines. Read More
Eur Rev Med Pharmacol Sci 2021 Sep;25(17):5402-5411
Department of Surgical Medical Sciences, Inonu University, Malatya, Turkey.
Objective: Chondroitin sulfate (CS) is a glycosaminoglycan with proven anti-inflammatory, anti-apoptotic, anti-oxidant properties. CS increases type II collagen and proteoglycan synthesis in human joint chondrocytes. CS can reduce the production of pro-inflammatory mediators and proteases to improve the anabolic/catabolic balance of the extracellular cartilage matrix (ECM). Read More