Contact Dermatitis 2021 Jun 15. Epub 2021 Jun 15.
Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Dermatitis 2011 May;22(3):E7-9
Department of Dermatology, Istanbul Medical Faculty, Turkey.
Fixed drug eruption (FDE) is a distinctive drug eruption characterized by recurrent well-defined lesions in the same location each time the responsible drug is taken. Two different clinical forms have been described: the common classic pigmenting form and the rare nonpigmenting form. Nonpigmenting FDE is mainly characterized by symmetrical large erythematous plaques and the dermal histopathologic reaction pattern. Read More
Ann Allergy Asthma Immunol 1998 Apr;80(4):309-10
Allergy Unit, Complejo Hospitalario Universitario de Santiago de Compostela (Hospital de Conxo), Spain.
Background: The nonpigmenting fixed drug eruption is a distinctive drug reaction characterized by large, tender and symmetric erythematous plaques that disappear with no residual pigmentation.Methods: A case of a non-pigmenting fixed drug eruption due to pseudoephedrine is reported.Result: The reappearance of typical lesions at the same sites after oral challenge with 60 mg pseudoephedrine together with the absence of pigmentation confirm the diagnosis. Read More
J Clin Microbiol 1996 Feb;34(2):376-84
Department of Periodontal Microbiology, Forsyth Dental Center, Boston, Massachusetts 02115, USA.
Eighty-nine species of subgingival bacteria, represented by 121 reference strains and 892 patient isolates, including gram-negative, gram-positive, aerobic, facultatively anaerobic, microaerophilic, and anaerobic species, were characterized with a panel of fluorogenic, 4-methylumbelliferyl-linked substrate tests. Identifications of all patient isolates were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of whole-cell proteins relative to reference strains. Characteristic profiles of positive fluorogenic reactions differentiated most of the species, including five Porphyromonas species, six pigmenting and five nonpigmenting Prevotella species, Bacteroides forsythus, three Capnocytophaga species, six Actinomyces species, four Propionibacterium species, and eight Streptococcus species. Read More
Dermatology 1996 ;193(3):248-50
Department of Dermatology-Phlebology, CHRU Montpellier, France.
We describe a new case of a seldom reported subset of fixed drug eruption, the nonpigmenting type. Aside from their fixed nature and their well-demarcated margins, pigmenting and non-pigmenting subsets of fixed drug eruption exhibit well-separated clinical and histological features allowing easy recognition. The precise physiopathology is currently unknown in both conditions, but a delayed hypersensitivity mechanism is likely. Read More