Clin Chem 2021 Jul;67(7):929-931
Department of Clinical Biochemistry, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Centre, Manchester, UK.
Biomed Pharmacother 2021 Jul 23;142:111939. Epub 2021 Jul 23.
The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510375, China. Electronic address:
Background And Aims: Osteosarcopenia (OS), characterized by the coexistence of osteoporosis (OP) and sarcopenia (SP), is associated with high morbidity and mortality in the elderly. Nevertheless, its pathogenesis and treatment remain unclear. The aim of this study was to investigate the effect and mechanism of Zhuanggu Zhitong Capsule (ZGZT) in OS rats. Read More
Biochem Biophys Res Commun 2021 Jul 15;570:96-102. Epub 2021 Jul 15.
Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, 300052, China. Electronic address:
Glucocorticoids are known to induce skeletal muscle atrophy by suppressing protein synthesis and promoting protein degradation. Tauroursodeoxycholic acid (TUDCA) has beneficial effects in several diseases, such as hepatobiliary disorders, hindlimb ischemia and glucocorticoid-induced osteoporosis. However, the effects of TUDCA on glucocorticoid -induced skeletal muscle atrophy remains unknown. Read More
Int J Biol Macromol 2021 Jul 16;186:864-872. Epub 2021 Jul 16.
Saint Petersburg State University, Institute of Chemistry, St. Petersburg, Peterhof, Universitetskii pr. 26, 198504, Russia. Electronic address:
Mucoadhesive formulations capable of situ gelation are promising for improving ocular drug delivery. Here we investigated two types of nanogels based on anionic glycosaminoglycans with grafted thermo-responsive poly(N-isopropylacrylamide) chains. One type of nanogels were formed by thermo-induced gelling of heparin-graft-poly(N-isopropylacrylamide) and chondroitin sulfate-graft-poly(N-isopropylacrylamide) copolymers. Read More
Cureus 2021 Jun 1;13(6):e15374. Epub 2021 Jun 1.
Critical Care, Mayo Clinic, Rochester, USA.
Severe acute respiratory syndrome coronavirus 2 pneumonia and acute pancreatitis are rarely reported in patients with coronavirus disease 2019 (COVID-19). We present the case of a 13-year-old girl who presented with nausea, vomiting, and abdominal pain for the last two days, along with a cough for the last week. She had a fever and tachycardia. Read More
J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jun 9;1179:122825. Epub 2021 Jun 9.
Waters Corporation, 34 Maple St, Milford, MA 01757, USA.
The accurate determination of the pharmacokinetics (PK) of a candidate drug molecule is critical in both drug discovery and development. Over the last 30 years, the sensitivity and selectivity of LC/MS has resulted in it being established as the technology of choice for these studies. However, unwanted chemical interactions between analyte(s) and the metal components in a chromatography system can result in poor peak shape and reduction in signal response, which can adversely affect the analysis of low concentrations of drugs and their metabolites in biological samples. Read More