Ann Oncol 2021 07 27;32(7):823-824. Epub 2021 Apr 27.
Universitätsklinikum Leipzig - Universitäres Krebszentrum Leipzig, Leipzig, Germany.
ESMO Open 2021 Jun 3;6(3):100130. Epub 2021 May 3.
ESMO Open 2021 Jun 23;6(3):100114. Epub 2021 Apr 23.
Department of Cancer Medicine, Gustave Roussy, Villejuif, France. Electronic address:
Background: Treatment strategies for metastatic breast cancer (MBC) have made great strides over the past 10 years. Real-world data allow us to evaluate the actual benefit of new treatments. ESME (Epidemio-Strategy-Medico-Economical)-MBC, a nationwide observational cohort (NCT03275311), gathers data of all consecutive MBC patients who initiated their treatment in 18 French Cancer Centres since 2008. Read More
ESMO Open 2020 07;5(4)
Department of Oncology, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Canada.
Background: Glioblastoma relapse is associated with activation of phosphatidylinositol 3-kinase (PI3K) signalling pathway. In preclinical studies, the pan-PI3K inhibitor buparlisib showed antitumour activity in glioma models.Methods: This was a two-part, multicentre, phase Ib/II study in patients with recurrent glioblastoma pretreated with radiotherapy and temozolomide standard of care. Read More