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Clin Nutr ESPEN 2022 Jun 23;49:417-424. Epub 2022 Mar 23.

Department of Gastroenterological Surgery, Himeji Medical Center, 68 Honmachi, Himeji City, Hyogo, 670-8520, Japan.

Background & Aims: Malnutrition and inflammation adversely affect the prognosis of patients with cancer. The Geriatric Nutritional Risk Index (GNRI) and systemic inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), lymphocyte-to-C reactive protein ratio (LCR), and C-reactive protein-to-albumin ratio (CAR), predict survival in colorectal cancer (CRC) patients. The present study aimed to examine the association of these two factors with CRC survival. Read More

Semin Cancer Biol 2022 May 24. Epub 2022 May 24.

Cancer Center and Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshedong Str., Zhengzhou, 450052, China. Electronic address:

Epigenetic regulation by microRNAs (miRs) demonstrated a promising therapeutic potential of these molecules to regulate genetic activity in different cancers, including colorectal cancers (CRCs). The RNA-based therapy does not change genetic codes in tumor cells but can silence oncogenes and/or reactivate inhibited tumor suppressor genes. In many cancers, specific miRs were shown to promote or stop tumor progression. Read More

Hum Pathol 2022 May 24. Epub 2022 May 24.

Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

Background: Recently published work on the Glasgow Microenvironment Score (GMS) demonstrated its relevance as a biomarker in TNM II-III colorectal cancer (CRC). Epithelial-to-Mesenchymal Transition (EMT) markers in colorectal cancer have also shown promise as prognostic biomarkers. This study aimed to assess the relationship between GMS and markers of EMT in stage II-III CRC. Read More

Biomed Pharmacother 2022 May 24;151:113145. Epub 2022 May 24.

Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain; Department of Anatomy and Embryology, Faculty of Medicine, University of Granada, 18071 Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18014 Granada, Spain.

The emergence of adverse effects and resistance to colorectal cancer (CRC) current therapies calls for the development of new strategies aimed at both preventing and treating. In this context, functional extracts from Brassicaceae family contains abundant bioactive compounds directly related to a positive effect on human health including cancer. The main objective of this systematic review is to compile all recent studies that analyzed the in vitro antiproliferative activity of functional extracts or isolated molecules from the Brassicaceae family against CRC. Read More

Medicine (Baltimore) 2022 May 27;101(21):e29244. Epub 2022 May 27.

Department of Gastroscope, Shuguang Hospital of Shanghai Traditional Chinese Medicine University, Shanghai, China.

Abstract: Preoperative T staging is closely related to operation planning and prognosis of colorectal cancer (CRC). This study aimed to re-investigate the value of computed tomography (CT) in T stage evaluation of CRC patients with both functional and radiomics parameters.The functional and radiomics parameters of CT images and the clinical information were collected from 32 CRC patients. Read More