Am J Cardiol 2021 Jul 8;150:128-129. Epub 2021 May 8.
Division of Cardiology, Department of Medicine, Henry Ford Health System, Detroit, Michigan.
Ann Biomed Eng 2021 Jun 11. Epub 2021 Jun 11.
Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, 304 Weill Hall, Ithaca, NY, 14853-7202, USA.
Mechanical forces are essential for proper growth and remodeling of the primitive pharyngeal arch arteries (PAAs) into the great vessels of the heart. Despite general acknowledgement of a hemodynamic-malformation link, the direct correlation between hemodynamics and PAA morphogenesis remains poorly understood. The elusiveness is largely due to difficulty in performing isolated hemodynamic perturbations and quantifying changes in-vivo. Read More
Placenta 2021 Jun 3;110:29-38. Epub 2021 Jun 3.
The Goldyne Savad Institute of Gene Therapy and MRI Laboratory, Human Biology Research Center, Hadassah Hebrew University Medical Center, Ein Karem, And the Faculty of Medicine, Hebrew University, Jerusalem, Israel; The Wohl Institute for Translational Medicine, Hadassah Hebrew University Medical Center, Ein Karem, And the Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Introduction: Brief hypercapnic challenge causes acute placental hypoperfusion with fetal brain sparing on BOLD-MRI. We hypothesize that this non-invasive imaging strategy can distinguish between normal pregnancy and chronic placental hypoperfusion (using the maternal hypoxia model).Methods: Eighteen pregnant female ICR mice were randomized to three groups: normoxia, late-onset hypoxia (12%O;E13. Read More
Heart Rhythm O2 2021 Feb 22;2(1):19-27. Epub 2021 Jan 22.
Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
Background: No periprocedural metric has demonstrated improved cardiac resynchronization therapy (CRT) outcomes in a multicenter setting.Objective: We sought to determine if left ventricular (LV) lead placement targeted to the coronary sinus (CS) branch generating the best acute hemodynamic response (AHR) results in improved outcomes at 6 months.Methods: In this multicenter randomized controlled trial, patients were randomized to guided CRT or conventional CRT. Read More
Eur Heart J Case Rep 2021 Mar 31;5(3):ytab030. Epub 2021 Mar 31.
Department of Medicine, Division of Cardiology, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada.
Background: Anomalous right coronary artery (RCA) from the pulmonary artery (ARCAPA) is a rare congenital heart abnormality with varying clinical presentations, for which multiple imaging modalities are often required for diagnosis.Case Summary: We present a case of a 76-year-old female presenting with 2 weeks of palpitations and shortness of breath who was found to be in rapid atrial fibrillation (AF) with congestive heart failure. Despite initial medical management, the patient developed cardiogenic shock with anuric renal failure. Read More
Internist (Berl) 2021 Jun 9. Epub 2021 Jun 9.
Klinik für Kardiologie und Pneumologie, Universitätsmedizin Göttingen, Deutsches Zentrum für Herz-Kreislauf-Forschung e. V., Standort Göttingen, Robert-Koch-Str. 40, 37099, Göttingen, Deutschland.
Myocardial ischemia is triggered by a mismatch between the oxygen supply and demand of the myocardial tissue. The most common cause is coronary artery disease; however, not every coronary stenosis is hemodynamically relevant and leads to myocardial ischemia. The guidelines recommend noninvasive ischemia diagnostics prior to invasive treatment in patients with chronic coronary syndrome. Read More