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Biomed Phys Eng Express 2022 Jun 30. Epub 2022 Jun 30.

Mechanical Engineering, Anna University Chennai, Department of Mechanical Engineering, College of Engineering Campus, CEG, Anna University, Chennai-25, Chennai, Tamilnadu, 600025, INDIA.

Electro-spinnable polymeric materials can easily form two-dimensional (2D) nanofibrous scaffolds improving biochemical functionalities specially in the area of skin wound healing and nanomedicine, but it has been hard to achieve this on a highly mechanically stable biopolymer, Poly ether ether ketone (PEEK), due to its intrinsic hydrophobicity and chemical inertness. Herein, we demonstrated a novel nanomedicine healing system consisting of sulphonated poly ether ether ketone combined with(SPEEK+RSV), which could act as an effective 2D nano bio-materialand, without observable cytotoxicity. The fabricated nanocomposites exhibited enriched skin cell proliferation and adhesion as confirmed from the results of MTT, cell adhesion and live-dead assay. Read More

Drug Alcohol Depend 2022 Jun 26;237:109543. Epub 2022 Jun 26.

The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.

Background: Injecting-related skin and soft tissue infections (SSTIs) are a preventable cause of inpatient hospitalisation among people who inject drugs (PWID). This study aimed to determine the prevalence of hospitalisation for SSTIs among PWID, and identify similarities and differences in factors associated with hospitalisation for SSTIs versus non-bacterial harms related to injecting drug use.

Methods: We performed cross-sectional analyses of baseline data from an observational cohort study of PWID attending drug treatment clinics and needle and syringe programs in Australia. Read More

Assay Drug Dev Technol 2022 Jun 30. Epub 2022 Jun 30.

Bharati Vidyappeth's Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, Maharashtra, India.

C Read More

ACS Appl Mater Interfaces 2022 Jun 30. Epub 2022 Jun 30.

Engineering Research Center of Nano-Geomaterials of the Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, China.

With the emergence and global spread of bacterial resistance, pathogenic bacterial infections have become a serious threat to human health. Thus, therapeutic strategies with highly antibacterial efficacy and a low tendency to induce drug resistance are strongly desired to combat bacterial infections. Here, an ultra-efficient photodynamic/chemodynamic theranostics platform is developed by intercalating an aggregation-induced emission (AIE) photosensitizer, TPCI, into the nanolayers of iron-bearing montmorillonite (MMT). Read More

ACS Biomater Sci Eng 2022 Jun 30. Epub 2022 Jun 30.

School of Pharmacy, Changzhou University, Changzhou 213164, Jiangsu, P. R. China.

As the most common pathogen of community and nosocomial infection, the resistance of () to traditional antibiotics is still increasing with years. Although the potent antibacterial activity of antimicrobial peptides (AMPs) has been widely confirmed, the unpredictable cytotoxicity remains the biggest obstacle to their clinical application. The development of a targeted drug delivery system for is a practical strategy to ameliorate the inherent limitations of AMPs. Read More