Clin Microbiol Infect 2021 Apr 26. Epub 2021 Apr 26.
Department of Microbiology, Amrita Institute of Medical Sciences & Research Centre, Amrita Vishwa Vidyapeetham, Ponekara, Kochi 682041, Kerala, India.
Molecules 2021 Jun 30;26(13). Epub 2021 Jun 30.
Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland.
Redox-active drugs are the mainstay of parasite chemotherapy. To assess their repurposing potential for eumycetoma, we have tested a set of nitroheterocycles and peroxides in vitro against two isolates of , the main causative agent of eumycetoma in Sudan. All the tested compounds were inactive except for niclosamide, which had minimal inhibitory concentrations of around 1 µg/mL. Read More
Antimicrob Agents Chemother 2021 Jun 28:AAC0043321. Epub 2021 Jun 28.
Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, Netherlands.
For many fungal infections, susceptibility testing is used to predict if an isolate is resistant or susceptible to the antifungal agent used to treat the fungal infection. For , the main causative agent of mycetoma, susceptibility testing currently is not performed on a routine basis. The current susceptibility testing method is labor intensive and sonication must be done to generate a hyphal inoculum. Read More
PLoS Negl Trop Dis 2021 Jun 9;15(6):e0009488. Epub 2021 Jun 9.
Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands.
Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus Madurella mycetomatis. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole and surgery. However, treatment is associated with low success rates. Read More
Indian J Med Microbiol 2021 Apr 2;39(2):256-258. Epub 2020 Nov 2.
Department of Dermatology, Institute of Post-Graduate Medical Education & Research, 244 AJC Bose Road, Kolkata, 700020, India.
Simultaneous double mycetoma is a rare presentation. Worldwide only three to four cases are found in literature. Here we report such an unusual case, to the best of our knowledge first documented case from India, where a 60 years old male farmer presented with double eumycetoma in different sites of same limb with discharge of black and white grains, which conventionally diagnosed as Madurella grisea from foot and Acremonium falciformi from buttock respectively. Read More