Eur J Cancer 2021 Jun 23;150:130-132. Epub 2021 Apr 23.
Dermatology Unit, Gustave Roussy Cancer Campus, Villejuif, France; Inserm U981, Gustave Roussy Cancer Campus, Villejuif, France; University Paris-Saclay, Faculty of Medicine, Kremlin-Bicêtre, France. Electronic address:
Aging (Albany NY) 2021 Jun 11;13. Epub 2021 Jun 11.
Department of Obstetrics and Gynecology, Changhai Hospital, Naval Military Medical University, Yangpu, Shanghai 200433, China.
Crystallins, the major constituent proteins of mammalian lenses, are significant not only for the maintenance of eye lens stability, transparency, and refraction, but also fulfill various physiopathological functions in extraocular tissues. βB2-crystallin, for example, is a multifunctional protein expressed in the human retina, brain, testis, ovary, and multiple tumors. Mutations in the βB2 crystallin gene or denaturation of βB2-crystallin protein are associated with cataracts, ocular pathologies, and psychiatric disorders. Read More
ESMO Open 2021 Jun 9;6(4):100178. Epub 2021 Jun 9.
Department of Drug Development and Innovation (D3i), Institut Curie, Paris and Saint-Cloud, France. Electronic address:
Background: Oral cavity is the most prevalent site of head and neck squamous cell carcinomas (HNSCCs). Most often diagnosed at a locally advanced stage, treatment is multimodal with surgery as the cornerstone. The aim of this study was to explore the molecular landscape of a homogenous cohort of oral cavity squamous cell carcinomas (OCSCCs), and to assess the prognostic value of tumor mutational burden (TMB), along with classical molecular and clinical parameters. Read More
Biochem Biophys Res Commun 2021 Jun 9;566:80-86. Epub 2021 Jun 9.
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. Electronic address:
Long non-coding RNAs (lncRNAs) are essential drivers or suppressors in human hepatocellular carcinoma (HCC) by participating in controlling transcription, translation, mRNA stability, and protein degradation protein-protein interaction. TM4SF1-AS1 is recently identified as a tumor-promoting factor in lung cancer. Nevertheless, its function in HCC and related molecular mechanisms remain unknown. Read More
Eur J Pharm Biopharm 2021 Jun 9. Epub 2021 Jun 9.
The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, P.R. China; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510799, P.R. China; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, P.R. China. Electronic address:
Vascular embolization is a well-known therapeutic treatment against hepatocellular carcinoma. However, existing embolic agents require complex synthesis, toxic organic solvents and sometimes produce only low yields. In this study, a novel photopolymerization technique, which addresses these issues, was used to prepare embolic microspheres successfully from the sucrose multi-allyl ether monomer in one step. Read More
J Ethnopharmacol 2021 Jun 9:114297. Epub 2021 Jun 9.
Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh. Electronic address:
Ethnopharmacological Relevance: Tabebuia pallida (Lindl.) Miers (T. pallida) is a well-known native Caribbean medicinal plant. Read More