Clin Exp Rheumatol 2021 Sep-Oct;39(5):1146. Epub 2021 Apr 7.
Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Res Vet Sci 2021 Sep 9;140:229-232. Epub 2021 Sep 9.
Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany. Electronic address:
Several non-variant of concern SARS-CoV-2 infections in pets have been reported as documented in the OIE and GISAID databases and there is only one fully documented case of an alpha variant of concern (VOC)(B.1.1. Read More
Curr Opin Virol 2021 Sep 8;50:173-182. Epub 2021 Sep 8.
Division of Molecular Medicine, Boston Children's Hospital, 3 Blackfan Street, Boston, MA 02115, United States; Department of Pediatrics, Harvard Medical School, 3 Blackfan Street, Boston, MA 02115, United States. Electronic address:
The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and devastating socio-economic consequences worldwide. The disease has created urgent needs for intervention strategies to control the crisis and meeting these needs requires a deep understanding of the structure-function relationships of viral proteins and relevant host factors. The trimeric spike (S) protein of the virus decorates the viral surface and is an important target for development of diagnostics, therapeutics and vaccines. Read More
Lancet Infect Dis 2021 Sep 14. Epub 2021 Sep 14.
Department of Immunobiology, New Haven, CT, USA; Yale University School of Medicine, New Haven, CT, USA; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address:
As the number of individuals vaccinated against SARS-CoV-2 rises worldwide, population-level data regarding the vaccines' ability to reduce infection are being generated. Randomised trials have shown that these vaccines dramatically reduce symptomatic COVID-19; however, less is known about their effects on transmission between individuals. The natural course of infection with SARS-CoV-2 involves infection of the respiratory epithelia and replication within the mucosa to sufficient viral titres for transmission via aerosol particles and droplets. Read More
Cell Rep 2021 Sep 8:109760. Epub 2021 Sep 8.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:
Many anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) neutralizing antibodies target the angiotensin-converting enzyme 2 (ACE2) binding site on viral spike receptor-binding domains (RBDs). Potent antibodies recognize exposed variable epitopes, often rendering them ineffective against other sarbecoviruses and SARS-CoV-2 variants. Class 4 anti-RBD antibodies against a less-exposed, but more-conserved, cryptic epitope could recognize newly emergent zoonotic sarbecoviruses and variants, but they usually show only weak neutralization potencies. Read More
J Infect Dis 2021 Sep 17. Epub 2021 Sep 17.
Maryland Institute for Applied Environmental Health, University of Maryland School of Public Health, College Park, Maryland, USA.
Mobile phones are among the most highly touched personal objects. As part of a broader study on the contribution of fomites to influenza transmission, between 2017-19, we swabbed mobile phones from 138 influenza patients in two locations. Influenza viral RNA detection rates were 23% (23/99) and 36% (14/39) in Hong Kong and Maryland, respectively. Read More