Clin Exp Dermatol 2021 Apr 9. Epub 2021 Apr 9.
Jephson Dermatology Centre, South Warwickshire NHS Foundation Trust, Warwick, UK.
Lancet Oncol 2021 May 12. Epub 2021 May 12.
Perlmutter Cancer Center at NYU Langone Health, New York, NY, USA.
Background: Locally advanced or metastatic urothelial carcinoma is generally incurable and has scarce treatment options, especially for cisplatin-ineligible patients previously treated with PD-1 or PD-L1 therapy. Enfortumab vedotin is an antibody-drug conjugate directed at Nectin-4, a protein highly expressed in urothelial carcinoma. We aimed to evaluate the efficacy and safety of enfortumab vedotin in the post-immunotherapy setting in cisplatin-ineligible patients. Read More
Br J Haematol 2021 May 15. Epub 2021 May 15.
Alfred Health-Monash University, Melbourne, Victoria, Australia.
We evaluated the efficacy and tolerability of continuous ixazomib-thalidomide-dexamethasone (ITd: 4 mg, day 1, 8, 15; 100 mg daily; and 40 mg weekly). A total of 39 patients with relapsed/refractory multiple myeloma (RRMM) aged ≥18 years with one to three prior lines of therapy were enrolled from two tertiary centres in Victoria and South Australia, Australia. The overall response rate (ORR) was 56·4% with a clinical benefit rate of 71·8%. Read More
JAMA Cardiol 2021 May 15. Epub 2021 May 15.
The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Importance: Shortened dual antiplatelet therapy followed by potent P2Y12 receptor inhibitor monotherapy reduces bleeding without increasing ischemic events after percutaneous coronary intervention (PCI).Objective: To explore sex differences and evaluate the association of sex with outcomes among patients treated with ticagrelor monotherapy vs ticagrelor plus aspirin.Design, Setting, And Participants: This was a prespecified secondary analysis of TWILIGHT, an investigator-initiated, placebo-controlled randomized clinical trial conducted at 187 sites across 11 countries. Read More
Pediatr Int 2021 May 15. Epub 2021 May 15.
National Center for Global Health and Medicine. Bureau of International Health Cooperation. Department of Human Resources Development.
Background: The present study compared adherence to the fasting-time guidelines of the International Committee for the Advancement of Procedural Sedation (ICAPS) and the North American Society of Anesthesiologists (ASA) and complication rates in pediatric patients requiring procedure sedation and analgesia during treatment in the emergency room (ER).Methods: The present, retrospective, single-center study was performed between 2016 and 2020 and enrolled patients who received procedural sedation and analgesia in the ER with the fasting times recommended in the ICAPS and ASA guidelines.Results: In total, 857 patients were included. Read More
Sci Rep 2021 May 14;11(1):10370. Epub 2021 May 14.
Laboratory of Clinical Chemistry and Mass Spectrometry, Department of Health Sciences, Università degli Studi di Milano, ASST-Santi Paolo e Carlo, via di Rudini' 8, 20142, Milan, Italy.
Low-dose aspirin (ASA) is used to prevent cardiovascular events. The most commonly used formulation is enteric-coated ASA (EC-ASA) that may be absorbed more slowly and less efficiently in some patients. To uncover these "non-responders" patients, the availability of proper analytical methods is pivotal in order to study the pharmacodynamics, the pharmacokinetics and the metabolic fate of ASA. Read More