Nat Genet 2021 04;53(4):416-419
Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.
Mol Cell Proteomics 2021 Jun 12:100096. Epub 2021 Jun 12.
Division of Neurosurgery, University of British Columbia, Vancouver, BC, Canada.
Despite the emergence of promising therapeutic approaches in preclinical studies, the failure of large-scale clinical trials leaves clinicians without effective treatments for acute spinal cord injury (SCI). These trials are hindered by their reliance on detailed neurological examinations to establish outcomes, which inflate the time and resources required for completion. Moreover, therapeutic development takes place in animal models whose relevance to human injury remains unclear. Read More
Oncogene 2021 Jun 14. Epub 2021 Jun 14.
Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Treatment of prostate cancer confronts resistance to androgen receptor (AR)-targeted therapies. AR-associated coregulators and chromatin proteins hold a great potential for novel therapy targets. Here, we employed a powerful chromatin-directed proteomics approach termed ChIP-SICAP to uncover the composition of chromatin protein network, the chromatome, around endogenous AR in castration resistant prostate cancer (CRPC) cells. Read More
AIDS 2021 Jun 14. Epub 2021 Jun 14.
Department of Infectious Diseases, King's College London, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK Medical Research Council/Uganda Virus Research Institute, Entebbe, Uganda Projeto Praça Onze, Hospital Escola São Francisco de Assis, Universidade Federal do Rio de Janeiro, Rio de Janeiro RJ 21941-901, Brazil Department of Infectious Diseases, Ospedale San Raffaele, Milan 20132, Italy Department of Medicine, Imperial College London, UK Infectious Diseases Service. Hospital Clinic-Institut d'investigacions Biomèdiques August Pi I Sunyer, University of Barcelona, Barcelona, Spain Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, United Kingdom MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology St Vincent's Centre for Applied Medical Research and The Kirby Institute, UNSW Australia, Sydney, New South Wales 2052, Australia Brighton and Sussex University Hospitals, Brighton, United Kingdom HIV Prevention Research Unit, South African Medical Research Council, Durban, South Africa Department of Infectious Disease, Imperial College London, London, UK; NIHR Imperial Biomedical Research Centre, London, UK Nuffield Department of Medicine, Oxford University, UK; Oxford NIHR Biomedical Research Centre, Oxford, UK King's College NIHR Research Biomedical Research Centre, London, UK Current Address, Imperial College London These Authors contributed equally to the work Deceased.
Objective: Development of immunogens that elicit an anti-HIV-1 broadly neutralizing antibody (bnAb) response will be a key step in the development of an effective HIV-1 vaccine. Although HIV-1 bnAb epitopes have been identified and mechanisms of action studied, current HIV-1 Envelope based immunogens do not elicit HIV-1 bnAbs in humans or animal models. A better understanding of how HIV-1 bnAbs arise during infection and the clinical factors associated with bnAb development may be critical for HIV-1 immunogen design efforts. Read More
BMC Genomics 2021 Jun 15;22(1):446. Epub 2021 Jun 15.
College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, EX2 5DW, UK.
Background: The combination of sodium bisulfite treatment with highly-parallel sequencing is a common method for quantifying DNA methylation across the genome. The power to detect between-group differences in DNA methylation using bisulfite-sequencing approaches is influenced by both experimental (e.g. Read More
Soc Sci Med 2021 Jun 2;281:114096. Epub 2021 Jun 2.
Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, 01655, USA; Center for Healthcare Organization and Implementation Research, Bedford VA Medical Center, Bedford, MA, 01730, USA.
Rationale: Mental health and substance use disorders are strong risk factors for homelessness. Understanding the role of transdiagnostic factors could help inform efforts to reduce homelessness among veterans with a range of disorders. Homeless veterans have high rates of trauma exposure, which can result in the depletion of social and emotional resources that may contribute to housing and employment stability. Read More