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Transplant Cell Ther 2022 May 13. Epub 2022 May 13.

Department of Hematology, National Defense Medical College Hospital, Saitama, Japan.

Background: Since cord blood (CB) units are usually selected based on the cell dose /kg, overweight (25 kg/m ≤ body mass index (BMI) < 30 kg/m) and obese (30 kg/m ≤ BMI) recipients tend to have difficulty in getting appropriate CB units. In general, actual body weight (ABW) is used for CB unit selection. However, ideal body weight (IBW) has been reported to be more closely correlated with successful engraftment after autologous, allogeneic bone marrow, and peripheral blood stem cell transplantation than ABW. Read More

Transplant Cell Ther 2022 May 13. Epub 2022 May 13.

Harvard Medical School, Boston MA; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital, Boston MA; Cancer Outcomes Research and Education Program, Massachusetts General Hospital Cancer Center, Boston MA.

Background/objective: Social support is essential to the recovery of patients who have undergone hematopoietic stem cell transplants (HSCT). We undertook a qualitative study to explore the specific sources and benefits of social support as experienced by HSCT recipients, as well as their unmet social support needs.

Methods: We conducted semi-structured interviews with 25 patients who had undergone HSCT and were recruited from the Dana Farber Cancer Institute's HSCT database. Read More

Regul Toxicol Pharmacol 2022 May 13:105184. Epub 2022 May 13.

BASF Österreich GmbH, Vienna, Austria. Electronic address:

The dermal absorption potential of C-Caffeine applied as a 4 mg/mL concentration (10 μL/cm finite dose) was investigated in six laboratories under Good Laboratory Practice conditions using an OECD TG 428-compliant in vitro assay with flow-through cells and split-thickness human skin. Potential sources of variation were reduced by a standardized protocol, test item and skin source. Particularly, skin samples from same donors were distributed over two repeats and between labs in a non-random, stratified design. Read More

PLoS Pathog 2022 May 16;18(5):e1010533. Epub 2022 May 16.

Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia.

Antagonism of the interferon (IFN)-mediated antiviral state is critical to infection by rabies virus (RABV) and other viruses, and involves interference in the IFN induction and signaling pathways in infected cells, as well as deactivation of the antiviral state in cells previously activated by IFN. The latter is required for viral spread in the host, but the precise mechanisms involved and roles in RABV pathogenesis are poorly defined. Here, we examined the capacity of attenuated and pathogenic strains of RABV that differ only in the IFN-antagonist P protein to overcome an established antiviral state. Read More

PLoS One 2022 16;17(5):e0267839. Epub 2022 May 16.

Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United States of America.

Thirdhand smoke (THS) is a newly described health hazard composed of toxicants, mutagens and carcinogens, including nicotine-derived tobacco specific nitrosamines (TSNAs), one of which is 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal (NNA). Although TSNAs are generally potent carcinogens, the risk of NNA, which is specific to THS, is poorly understood. We recently reported that THS exposure-induced adverse impact on DNA replication and transcription with implications in the development of cancer and other diseases. Read More