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Biomater Sci 2022 May 24. Epub 2022 May 24.

Department of Chemical and Biological Engineering, Gachon University, 1342 Seongnam-daero, Seongnam-si, Gyeonggi-do 13120, Republic of Korea.

Upregulation of certain enzymes, such as collagenase, tyrosinase, and elastase, is triggered by several extrinsic environmental factors, such as temperature, UV radiation, humidity, and stress, and leads to elasticity loss and skin pigmentation. Herein, dual-emissive polyaromatic carbon quantum dots (CQDs) with abundant phenolic moieties, that is green and yellow CQDs (G-CQDs and Y-CQDs, respectively), were prepared using a three-fold symmetric molecule, 1,3,5-trihydroxybenzene. The significant inhibition efficacy of the fabricated CQDs against collagenase, elastase, and tyrosinase, which play important roles in skin aging, revealed their excellent antiaging potential. Read More

Small 2022 May 23:e2106357. Epub 2022 May 23.

Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.

It is well-known that tissue engineering scaffolds that feature highly interconnected and size-adjustable micropores are oftentimes desired to promote cellular viability, motility, and functions. Unfortunately, the ability of precise control over the microporous structures within bioinks in a cytocompatible manner for applications in 3D bioprinting is generally lacking, until a method of micropore-forming bioink based on gelatin methacryloyl (GelMA) was reported recently. This bioink took advantage of the unique aqueous two-phase emulsion (ATPE) system, where poly(ethylene oxide) (PEO) droplets are utilized as the porogen. Read More

Int J Biol Macromol 2022 May 16;212:67-84. Epub 2022 May 16.

School of Chemistry and Life Science, Suzhou University of Science and Technology, Suzhou 215009, China.

Multi-network hydrogels with high strength and toughness have attracted increasing attention. Herein, a hybrid hydrogel consisting of alginate, gelatin, and polyacrylamide was constructed with the combination of advantages of natural and synthetic polymers. Alginate grafted with host-guest complex of βCD/Ad-AAm was first prepared, namely Alg-βCD/Ad-AAm, then further crosslink with gelatin methacryloyl (GelMA) to form hydrogel via one-step UV light initiation. Read More

Biomater Sci 2022 May 18. Epub 2022 May 18.

College of Biological Science and Engineering, Fuzhou University, No. 2 Xueyuan Road, Fuzhou 350108, China.

Multidrug-resistant bacteria infections frequently occur in wound care due to the excessive use of antibiotics. It can cause scar formation, wound closure delay, multiple organ failure, and high mortality. Here, a double network hydrogel with injectability, hemostasis, and antibacterial activity was developed to prompt multidrug-resistant bacteria infected wound healing. Read More

Acta Biomater 2022 May 16. Epub 2022 May 16.

Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and the 4th Medical Center of Chinese PLA General Hospital, Beijing, 100048, China; Chinese PLA Medical School, Beijing, 100853, China; Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051, Beijing, 100048, China; PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Beijing, 100048, China. Electronic address:

Endothelial malfunction is responsible for impaired angiogenesis in diabetic patients, thereby causing the delayed healing progress of diabetic wounds. Exosomes or extracellular vesicles (EVs) have emerged as potential therapeutic vectors carrying drug cargoes to diseased cells. In the present study, EVs were reported as a new treatment for diabetic wounds by delivering VH298 into endothelial cells. Read More