Chin Med J (Engl) 2021 Mar 25. Epub 2021 Mar 25.
Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
J Vet Intern Med 2021 May 7. Epub 2021 May 7.
Evidensia Small Animal Hospital 'Hart van Brabant', Waalwijk, The Netherlands.
Background: Acquired narcolepsy has rarely been reported in veterinary medicine.Objective: To describe the presentation, clinicopathological features, diagnostic imaging findings, and management of dogs with suspected-acquired narcolepsy.Animals: Eight dogs with clinical features consistent with acquired narcolepsy. Read More
Sleep Med Rev 2021 Apr 5;58:101488. Epub 2021 Apr 5.
Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Mental Health Center, Translational Neuroscience Center, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. Electronic address:
Polysomnographic studies have been conducted to explore nighttime sleep features in narcolepsy, but their relationship to narcolepsy is still imperfectly understood. We conducted a systematic review of the literature exploring polysomnographic differences between narcolepsy patients and healthy controls (HCs) in EMBASE, MEDLINE, All EBM databases, CINAHL, and PsycINFO. 108 studies were identified for this review, 105 of which were used for meta-analysis. Read More
Neurology 2021 Apr 30. Epub 2021 Apr 30.
Neurology Department, Saint Antoine Hospital, AP-HP, Paris.
Objective: To evaluate sleepiness and central hypersomnia in multiple sclerosis (MS) associated fatigue, we performed long term polysomnography in MS patients and healthy controls.Methods: Patients with MS and healthy controls completed questionnaires on sleep, fatigue, sleepiness, and depression. They underwent nocturnal polysomnography, multiple sleep latency tests and bed rest 24-hour polysomnography. Read More
Turk J Pediatr 2021 ;63(2):334-338
Pediatric Neurology, Ağrı State Hospital, Ağrı, Turkey.
Background: Narcolepsy is a chronic neurological syndrome, which is characterized by excessive sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis during the rapid eye movement period of sleep. This disease is commonly diagnosed within adulthood. However, the first symptoms often appear in childhood and/or adolescence. Read More
Hum Psychopharmacol 2021 Apr 26:e2791. Epub 2021 Apr 26.
Centre for Addiction and Mental Health (CAMH), Addiction Imaging Research Group, Toronto, ON, Canada.
Objective: To establish in an exploratory neuroimaging study whether γ-hydroxybutyrate (sodium oxybate [SO]), a sedative, anti-narcoleptic drug with abuse potential, transiently inhibits striatal dopamine release in the human.Methods: Ten healthy participants (30 years; 6M, 4F) and one participant with narcolepsy received a baseline positron emission tomography scan of [C-11]raclopride, a D2/3 dopamine receptor radioligand sensitive to dopamine occupancy, followed approximately one week later by an oral sedative 3g dose of SO and two [C-11]raclopride scans (1 h, 7 h post SO). Plasma SO levels and drowsiness duration were assessed. Read More