Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

A Systematic Review of Randomized Controlled Trials Comparing Buccal Mucosal Graft Harvest Site Non-Closure Closure in Patients Undergoing Urethral Reconstruction.

Authors:
Eu Chang Hwang Adam de Fazio Kallie Hamilton Caitlin Bakker Joseph J Pariser Philipp Dahm

World J Mens Health 2021 Feb 15. Epub 2021 Feb 15.

Department of Urology, University of Minnesota, Minneapolis, MN, USA.

Purpose: To assess the effects of buccal mucosal graft site non-closure versus closure on postoperative oral morbidity for male undergoing augmentation urethroplasty for urethral stricture.

Materials And Methods: We included randomized controlled trials. Inclusion criteria were male over the age of 18 with urethral stricture disease requiring reconstruction with buccal mucosal graft harvest. Primary outcomes of the review were postoperative oral pain, need for secondary oral procedures and cosmetic defects.

Results: We included 5 studies with 346 randomized patients with urethral strictures, of whom 260 completed the trials. In terms of primary outcomes, non-closure graft site may reduce oral pain on postoperative day #1 (standard mean difference [SMD] 0.24 lower; 95% confidence interval [CI] 0.61 lower to 0.12 higher; low certainty evidence [CoE]) but we are uncertain how this impacts pain on postoperative days 3 to 6 (SMD 0.35; 95% CI 0.12 to 0.81 higher; very low CoE). We are also very uncertain as to how it affects the need for secondary oral procedures (risk ratio [RR] 0.22; 95% CI 0.01 to 4.28; very low CoE). Non-closure may increase the risk of cosmetic defects (RR 2.40; 95% CI 0.93 to 6.22; low CoE).

Conclusions: This review describes the trade-off for buccal mucosal graft site non-closure versus closure for various patient-important outcomes; decision-making will likely hinge on the relative value individual patients and surgeons place on them. The supporting evidence was rated as low and very low, thereby signaling substantial underlying uncertainty and the need for better trials.

Download full-text PDF

 Source
http://dx.doi.org/10.5534/wjmh.200175DOI Listing
February 2021

Publication Analysis

Top Keywords

buccal mucosal
16
mucosal graft
16
graft site
12
site non-closure
12
oral pain
8
postoperative oral
8
versus closure
8
pain postoperative
8
low coe
8
non-closure versus
8
primary outcomes
8
graft harvest
8
controlled trials
8
oral procedures
8
randomized controlled
8
secondary oral
8
higher low
8
low
6
non-closure
5
oral
5

Keyword Occurance

Similar Publications

Oro-facial tuberculosis - Is it still an enigmatic entity?

Authors:
Latika Gupta Anusha S Bhatt Varuna Mallya Deepika Rana Nita Khurana Ishwar Singh

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):250-253

Department of Otorhinolaryngology, MAMC, New Delhi, India.

Background And Aims: The objective of this study was to analyze and review the clinical and histopathological aspects of oro-facial tuberculosis.

Methods: Sixteen cases of oral mucosal biopsies diagnosed as granulomatous pathology consistent with tuberculosis were retrieved from the data base and clinical information and histopathological findings were analyzed retrospectively.

Results: Of the total 16 cases, 12 were males while 4 were females. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

A Cross-sectional Study to Evaluate Nuclear Changes in Buccal Mucosa Following Panoramic Radiography.

Authors:
Kalaiselvi Santhosh Sathick Manzoor Anu Sushanth Sakthidaran Seralathan Vivekanandan Rajasekar Anoop Jacob

J Contemp Dent Pract 2020 Nov 1;21(11):1258-1261. Epub 2020 Nov 1.

Department of Pedodontics, Educare Institute of Dental Sciences, Mundiyanthara, Kerala, India.

Aim And Objective: To evaluate the possible genotoxic effect of X-rays on buccal mucosa while exposing to dental panoramic radiography using micronucleus test.

Materials And Methods: The study group comprised of 30 healthy subjects, 15 males and 15 females, aged between 24 years and 65 years. Samples were obtained from the exfoliated oral mucosa cells of buccal mucosa before and 12 days after exposing the patients to panoramic radiography. Read More

View Article and Full-Text PDF
November 2020
Similar Publications

Safety and Efficacy of Trans-Perineal Urethroplasty for Management of Post-Traumatic Urethral Strictures in Pediatric Age-Group.

Authors:
Radheshyam Chaudhari Amit Sharma Irfan Shaikh Mukund Andankar Hemant Pathak

Urol Int 2021 Apr 13:1-5. Epub 2021 Apr 13.

Department of Urology, TNMC & BYL Nair Hospital, Mumbai, India.

Introduction: Trans-perineal urethroplasty is the preferred treatment for distraction urethral injuries in adults. However, management of such injuries in children is challenging because of functional implications in a growing child. In the present study, we aim to evaluate the safety and efficacy of perineal urethroplasty for distraction urethral injuries in children. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Various wound closure ways after impacted lower wisdom teeth removal: A review.

Authors:
Žygimantas Petronis Jonas Zigmantavičius Albinas Gervickas

Stomatologija 2020 ;22(4):107-115

Department of Maxillofacial, Faculty of Dentistry, Lithuanian University of Health Sciences, Eivenių g. 2, LT-50161 Kaunas Lithuania.

Objective: Evaluate the influence of different wound closure methods in terms of pain, swelling, trismus, infection and healing time after third molar extraction.

Material And Methods: A literature analysis was performed according to PRISMA guidelines in search of clinical trials published between 2015 and 2020. Databases were searched using different combinations of the following keywords: mandibular impacted OR retained wisdom teeth OR third molar removal OR extraction AND surgical removal AND discomfort OR pain OR trismus OR swelling AND drain OR drainage. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

A 3D Polymer Scaffold Platform for Enhanced Culture of Human & Rabbit Buccal Epithelial Cells for Cell Therapies.

Authors:
Shojiro Katoh Srinivas K Rao Vaddi Suryaprakash Akio Horiguchi Toshihiro Kushibiki Kenichiro Ojima Masayuki Shinchi Masaru Iwasaki Masayuki Takeda Rajappa Senthilkumar Mathaiyan Rajmohan Ramalingam Karthick Senthilkumar Preethy Samuel Jk Abraham

Tokai J Exp Clin Med 2021 Apr 20;46(1):1-6. Epub 2021 Apr 20.

II Department of Surgery & Center for Advancing Clinical Research (CACR), University of Yamanashi, Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi 409-3898, Japan.

Background: Buccal mucosal epithelial cells show promising application for various regenerative medicine approaches. In this study, we examined the feasibility of culturing rabbit and human buccal mucosal epithelial cells in a novel thermoreversible gelation polymer (TGP) scaffold, without feeder layers or other foreign proteins.

Methods & Results: The results of this 28-day culture, u sing the conventional technique (2D) and TGP (3D) showed that the epithelial cell morphology could be maintained only in the TGP group while cells in the 2D group de-differentiated to fibroblast morphology in both human and rabbit samples. Read More

View Article and Full-Text PDF
April 2021
Similar Publications